Publication Name	World Journal of Gastroenterology
Manuscript ID	53933
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis: An opinion review
Manuscript Source	Invited Manuscript
All Author List	Paul Brennan, Kathleen Clare, Jacob George and John F Dillon
Funding Agency and Grant Number
Corresponding Author	Paul Brennan, MBChB, MRCP, Doctor, Department of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Kirsty Semple Way, Dundee DD1 9SY, United Kingdom. p.z.brennan@dundee.ac.uk
Key Words	Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Uric acid; Urate; Non-invasive fibrosis markers; Fatty liver index
Core Tip	There is significant interest in the role of uric acid as both a causative aetiological proponent in non-alcoholic fatty liver disease as well as its diagnostic utility in the diagnosis of fatty liver disease. Within this review we explore these putative molecular mechanisms which are likely implicated, in addition to exploring the most recent translational evidence of uric acid as a diagnostic tool in the clinical environ.
Citation	Brennan P, Clare K, George J, Dillon JF. Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis: An opinion review. World J Gastroenterol 2020; 26(15): 1683-1690

Received	2019-12-31 20:58
Peer-Review Started	2019-12-31 20:59
To Make the First Decision
Return for Revision	2020-03-06 05:04
Revised	2020-04-02 21:53
Second Decision	2020-04-07 10:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-04-08 04:45
Articles in Press	2020-04-08 04:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-15 23:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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