Publication Name	World Journal of Gastroenterology
Manuscript ID	53944
Country	United States

Category	Immunology
Manuscript Type	Minireviews
Article Title	Regulation of macrophage activation in the liver after acute injury: Role of the fibrinolytic system
Manuscript Source	Invited Manuscript
All Author List	Katherine Roth, Jenna Strickland and Bryan L Copple
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health Grant DK073566 National Institutes of Health Training Grant ES007255
Corresponding Author	Bryan L Copple, PhD, Associate Professor, Research Associate, Department of Pharmacology and Toxicology, Institute for Integrative Toxicology, Michigan State University, 1355 Bogue Street, East Lansing, MI 48824, United States. copple@msu.edu
Key Words	Macrophage; Plasmin; Acetaminophen; Liver injury; Liver repair;
Core Tip	Macrophages contribute to repair of the liver after injury. After injury, Kupffer cells release cytokines that recruit monocyte-derived macrophages that phagocytose dead cell debris. These cells switch phenotype becoming pro-restorative macrophages that terminate cytokine synthesis and produce pro-mitogenic growth factors that facilitate liver repair.
Citation	Roth K, Strickland J, Copple BL. Regulation of macrophage activation in the liver after acute injury: Role of the fibrinolytic system. World J Gastroenterol 2020; 26(16): 1879-1887

Received	2020-01-07 18:37
Peer-Review Started	2020-01-07 18:37
To Make the First Decision
Return for Revision	2020-03-06 04:57
Revised	2020-03-31 21:43
Second Decision	2020-04-07 10:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-04-08 04:44
Articles in Press	2020-04-08 04:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-27 06:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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