Publication Name	World Journal of Gastroenterology
Manuscript ID	54470
Country	Poland

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection
Manuscript Source	Invited Manuscript
All Author List	Małgorzata Kujawska and Jadwiga Jodynis-Liebert
Funding Agency and Grant Number	Funding Agency Grant Number National Science Centre 2017/26/D/NZ7/00748
Corresponding Author	Małgorzata Kujawska, MSc, PhD, Adjunct Professor, Associate Professor, Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, Poznan 60631, Poland. kujawska@ump.edu.pl
Key Words	Urolithin A; Colonic metabolite; Gut microbiota; Colorectal cancer; Inflammatory bowel diseases; Hepatocellular carcinoma
Core Tip	Urolithin A (UA) - an ellagitannin metabolite generated by the intestinal bacteria at physiologically relevant micromolar concentrations, offers gastrointestinal (GI) protection. The health benefit is principally related to anticancer and anti-inflammatory effects. UA can regulate multiple tumor and inflammatory signaling pathways and enzyme activities, including those involved in carcinogen biotransformation and antioxidant defense. The presented herein data support the potential of both pure compound and in vivo generated UA in treatment interventions against GI ailments.
Citation	Kujawska M, Jodynis-Liebert J. Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection. World J Gastroenterol 2020; 26(23): 3170-3181

Received	2020-01-31 13:51
Peer-Review Started	2020-01-31 13:51
To Make the First Decision
Return for Revision	2020-04-09 16:41
Revised	2020-05-19 14:30
Second Decision	2020-05-22 08:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-05-23 01:01
Articles in Press	2020-05-23 01:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-06-18 13:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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