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Publication Name World Journal of Gastroenterology
Manuscript ID 54470
Country/Territory Poland
Category Biochemistry and Molecular Biology
Manuscript Type Review
Article Title Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection
Manuscript Source Invited Manuscript
All Author List Małgorzata Kujawska and Jadwiga Jodynis-Liebert
Funding Agency and Grant Number
Funding Agency Grant Number
National Science Centre 2017/26/D/NZ7/00748
Corresponding author Małgorzata Kujawska, MSc, PhD, Adjunct Professor, Associate Professor, Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, Poznan 60631, Poland. kujawska@ump.edu.pl
Keywords Urolithin A; Colonic metabolite; Gut microbiota; Colorectal cancer; Inflammatory bowel diseases; Hepatocellular carcinoma
Core Tip Urolithin A (UA) - an ellagitannin metabolite generated by the intestinal bacteria at physiologically relevant micromolar concentrations, offers gastrointestinal (GI) protection. The health benefit is principally related to anticancer and anti-inflammatory effects. UA can regulate multiple tumor and inflammatory signaling pathways and enzyme activities, including those involved in carcinogen biotransformation and antioxidant defense. The presented herein data support the potential of both pure compound and in vivo generated UA in treatment interventions against GI ailments.
Citation Kujawska M, Jodynis-Liebert J. Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection. World J Gastroenterol 2020; In press
Received
2020-01-31 13:51
Peer-Review Started
2020-01-31 13:51
To Make the First Decision
Return for Revision
2020-04-09 16:41
Revised
2020-05-19 14:30
Second Decision
2020-05-22 08:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-23 01:01
Articles in Press
2020-05-23 01:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ying Dou
Reviewer Code 03478404, and 01434943
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 54470-Review.docx
Answering Reviewers 54470-Answering reviewers.pdf
Audio Core Tip 54470-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 54470-Conflict-of-interest statement.pdf
Copyright License Agreement 54470-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54470-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 54470-Language certificate.pdf
Peer-review Report 54470-Peer-review(s).pdf
Scientific Misconduct Check 54470-Scientific misconduct check.pdf
Scientific Editor Work List 54470-Scientific editor work list.pdf