Publication Name	World Journal of Stem Cells
Manuscript ID	54474
Country	China

Category	Orthopedics
Manuscript Type	Review
Article Title	Insights of stem cell-based endogenous repair of intervertebral disc degeneration
Manuscript Source	Invited Manuscript
All Author List	Yang Liu, Yan Li, Li-Ping Nan, Feng Wang, Shi-Feng Zhou, Xin-Min Feng, Hao Liu and Liang Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81972136 National Natural Science Foundation for Young Scholars of China 81401830 Guangxi Natural Science Foundation General Project 2018JJA14775 Young Medical Scholars Major Program of Jiangsu Province QNRC2016342 Innovation Team Project of Jiangsu Province CXTDB2017004 Key Funding Project of Maternal and Child Health Research of Jiangsu Province F201801
Corresponding Author	Liang Zhang, MD, PhD, Academic Research, Assistant Professor, Associate Chief Physician, Chief Doctor, Research Scientist, Surgeon, Department of Orthopedics, Clinical Medical College of Yangzhou University, No. 98, Nantong West Road, Yangzhou 225000, Jiangsu Province, China. zhangliang6320@sina.com
Key Words	Low back pain; Intervertebral disc degeneration; Stem cell niche; Stem/progenitor cell; Endogenous repair strategy; Stem cell treatment
Core Tip	Low back pain has become more prevalent and brought enormous economic burden in recent years. However, therapies including conservative treatment, surgery and cell-based treatment still have several defects. Endogenous repair is a novel therapeutic strategy of intervertebral disc degenerative disease that draws increased attention. We review the research regarding endogenous repair strategy which using stem/progenitor cells as main cell resource, concluding and analyzing the status at present and perspective of endogenous repair strategy in future.
Citation	Liu Y, Li Y, Nan LP, Wang F, Zhou SF, Feng XM, Liu H, Zhang L. Insights of stem cell-based endogenous repair of intervertebral disc degeneration. World J Stem Cells 2020; 12(4): 266-276

Received	2020-02-01 05:49
Peer-Review Started	2020-02-01 05:49
To Make the First Decision
Return for Revision	2020-03-05 21:54
Revised	2020-03-26 07:28
Second Decision	2020-04-04 06:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-04-05 16:09
Articles in Press	2020-04-05 16:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-04-08 01:42
Typeset the Manuscript	2020-04-24 04:50

ISSN	1948-0210 (online)
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