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6/25/2020 4:56:08 AM | Browse: 29 | Download: 8
Publication Name World Journal of Meta-Analysis
Manuscript ID 54481
Country/Territory United States
Category Oncology
Manuscript Type Review
Article Title Immunotherapy in hepatocellular carcinoma: Combination strategies
Manuscript Source Invited Manuscript
All Author List Alexander Claudius Jordan and Jennifer Wu
Funding Agency and Grant Number
Corresponding author Jennifer Wu, MD, Associate Professor, Division of Hematology and Oncology, Perlmutter Cancer Center, New York University Langone Medical Center, 550 1st Avenue, New York, NY10016, United States. jennifer.wu@nyulangone.org
Keywords Hepatocellular carcinoma; Liver neoplasms; Antineoplastic agents; Immunological; Protein kinase inhibitors; Angiogenesis inhibitors
Core Tip Immunotherapy remains a viable option for the systemic treatment of patients with unresectable hepatocellular carcinoma, although nivolumab and pembrolizumab failed to meet their endpoints in phase III studies. Combining immunotherapy with other treatment modalities may improve treatment responses. Multiple clinical trials are evaluating the safety and efficacy of these new combination strategies, which involve pairing PD-1 or PD-L1 inhibitors with CTLA-4 inhibitors, or pairing checkpoint inhibitors with alternative agents or non-pharmacologic therapies.
Citation Jordan AC, Wu J. Immunotherapy in hepatocellular carcinoma: Combination strategies. World J Meta-Anal 2020; In press
Received
2020-02-01 07:58
Peer-Review Started
2020-02-01 07:58
To Make the First Decision
2020-02-26 11:22
Return for Revision
2020-02-27 15:14
Revised
2020-06-23 00:14
Second Decision
2020-06-24 08:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-06-25 04:56
Articles in Press
2020-06-25 04:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-07-05 04:30
ISSN 2308-3840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Le Zhang
Reviewer Code 01328488, 02861333, and 02438768
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor Li-Li Wang
Responsible Electronic Editor Lu-Lu Qi
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 54481-Review.docx
Answering Reviewers 54481-Answering reviewers.pdf
Audio Core Tip 54481-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 54481-Conflict-of-interest statement.pdf
Copyright License Agreement 54481-Copyright license agreement.pdf
Peer-review Report 54481-Peer-review(s).pdf
Scientific Misconduct Check 54481-Scientific misconduct check.pdf
Scientific Editor Work List 54481-Scientific editor work list.pdf