Publication Name	World Journal of Meta-Analysis
Manuscript ID	54481
Country	United States

Category	Oncology
Manuscript Type	Review
Article Title	Immunotherapy in hepatocellular carcinoma: Combination strategies
Manuscript Source	Invited Manuscript
All Author List	Alexander Claudius Jordan and Jennifer Wu
Funding Agency and Grant Number
Corresponding Author	Jennifer Wu, MD, Associate Professor, Division of Hematology and Oncology, Perlmutter Cancer Center, New York University Langone Medical Center, 550 1st Avenue, New York, NY 10016, United States. jennifer.wu@nyulangone.org
Key Words	Hepatocellular carcinoma; Liver neoplasms; Antineoplastic agents; Immunological; Protein kinase inhibitors; Angiogenesis inhibitors
Core Tip	Immunotherapy remains a viable option for the systemic treatment of patients with unresectable hepatocellular carcinoma, although nivolumab and pembrolizumab failed to meet their endpoints in phase III studies. Combining immunotherapy with other treatment modalities may improve treatment responses. Multiple clinical trials are evaluating the safety and efficacy of these new combination strategies, which involve pairing PD-1 or PD-L1 inhibitors with CTLA-4 inhibitors, or pairing checkpoint inhibitors with alternative agents or non-pharmacologic therapies.
Citation	Jordan AC, Wu J. Immunotherapy in hepatocellular carcinoma: Combination strategies. World J Meta-Anal 2020; 8(3): 190-209

Received	2020-02-01 07:58
Peer-Review Started	2020-02-01 07:58
To Make the First Decision	2020-02-26 11:22
Return for Revision	2020-02-27 15:14
Revised	2020-06-23 00:14
Second Decision	2020-06-24 08:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-06-25 04:56
Articles in Press	2020-06-25 04:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-07-05 04:30

ISSN	2308-3840 (online)
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