Publication Name	World Journal of Gastroenterology
Manuscript ID	54515
Country	Australia

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford
Manuscript Source	Unsolicited Manuscript
All Author List	Samba Siva Reddy Pulusu, Ashish Srinivasan, Krupa KrishnaPrasad, Daniel Cheng, Jakob Begun, Charlotte Keung, Daniel Van Langenberg, Lena Thin, Tamara Mogilevski, Peter De Cruz, Graham Radford-Smith, Emma Flanagan, Sally Bell, Soleiman Kashkooli, Miles Sparrow, Simon Ghaly, Peter Bampton, Elise Sawyer, Susan Connor, Quart-ul-ain Rizvi, Jane M Andrews, Gillian Mahy, Paola Chivers, Simon Travis and Ian Craig Lawrance
Funding Agency and Grant Number
Corresponding Author	Ian Craig Lawrance, FRCP (Hon), MBBS, PhD, Professor, Centre for Inflammatory Bowel Diseases, St John of God Hospital, 25 McCourt Street, Subiaco 6008, Western Australia, Australia. ian.lawrance@uwa.edu.au
Key Words	Vedolizumab; Ulcerative colitis; Outcomes; ; ;
Core Tip	Vedolizumab (VDZ) is a gut selective anti-integrin used for treatment of Ulcerative colitis (UC). Evidence is needed to support its use in real life setting involving multiple centers and two countries to reduce physician, site and country biases. This is a retrospective review of prospectively collected database involving 303 UC patients from Australia and Oxford, United Kingdom treated with VDZ. Clinical response was observed in 79% of patients at 3 mo and clinical remission in 56%, 62% and 60% at 3 mo, 6 mo and 12 mo respectively. Anti-tumor necrosis factor (anti-TNF) naïve patients were 1.8 times more likely to achieve remission than anti-TNF exposed and 11% of patients required colectomy by 12 mo. We concluded that VDZ is a safe and effective biologic medication used for treatment of UC.
Citation	Pulusu SSR, Srinivasan A, Krishnaprasad K, Cheng D, Begun J, Keung C, Van Langenberg D, Thin L, Mogilevski T, De Cruz P, Radford-Smith G, Flanagan E, Bell S, Kashkooli S, Sparrow M, Ghaly S, Bampton P, Sawyer E, Connor S, Rizvi Q, Andrews JM, Mahy G, Chivers P, Travis S, Lawrance IC. Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford. World J Gastroenterol 2020; 26(30): 4428-4441

Received	2020-04-04 11:32
Peer-Review Started	2020-04-04 11:33
To Make the First Decision
Return for Revision	2020-04-26 21:10
Revised	2020-07-18 04:47
Second Decision	2020-07-28 10:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-07-30 05:38
Articles in Press	2020-07-30 05:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-08-14 01:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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