Publication Name	World Journal of Gastroenterology
Manuscript ID	54575
Country	Germany

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Golimumab in real-world practice in patients with ulcerative colitis: Twelve-month results
Manuscript Source	Unsolicited Manuscript
All Author List	Niels Teich, Harald Grümmer, Eric Jörgensen, Thomas Liceni, Frank Holtkamp-Endemann, Tim Fischer and Susanne Hohenberger
Funding Agency and Grant Number	Funding Agency Grant Number MSD Sharp and Dohme GmbH, Haar, Germany
Corresponding Author	Niels Teich, MD, Doctor, Internistische Gemeinschaftspraxis für Verdauungs-und Stoffwechselkrankheiten Leipzig und Schkeuditz, Nordstr. 21, Leipzig 04105, Germany. teich@igvs.de
Key Words	Ulcerative colitis; Quality of life; Work productivity; Non-interventional study; Golimumab; Work Productivity Activity Impairment Questionnaire
Core Tip	Systematic reviews indicate that ulcerative colitis (UC) causes a significant socioeconomic burden, but prospective studies are scarce. The aim of this study is to evaluate the changes in work productivity and quality of life (QoL) of UC patients in Germany treated with the human monoclonal tumor necrosis factor alpha antibody golimumab in order to assess the specific benefit of this treatment option. This prospective non-interventional study included 287 patients. Based on these data we were able to show that treatment of moderate-to-severe UC with golimumab leads to significant improvements in patient´s work productivity, daily activity and QoL over twelve months.
Citation	Teich N, Grümmer H, Jörgensen E, Liceni T, Holtkamp-Endemann F, Fischer T, Hohenberger S. Golimumab in real-world practice in patients with ulcerative colitis: Twelve-month results. World J Gastroenterol 2020; 26(21): 2852-2563

Received	2020-02-06 09:57
Peer-Review Started	2020-02-06 09:57
To Make the First Decision
Return for Revision	2020-03-21 23:04
Revised	2020-05-08 07:37
Second Decision	2020-05-22 10:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-05-23 01:01
Articles in Press	2020-05-23 01:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-06-03 08:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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