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9/25/2020 7:23:42 PM | Browse: 119 | Download: 263
Publication Name World Journal of Stem Cells
Manuscript ID 54582
Country/Territory China
Category Hematology
Manuscript Type Letter to the Editor
Article Title Acquired aplastic anemia: Is bystander insult to autologous hematopoiesis driven by immune surveillance against malignant cells?
Manuscript Source Unsolicited Manuscript
All Author List Xi-Chen Zhao, Xiao-Yun Sun, Bo Ju, Fan-Jun Meng and Hong-Guo Zhao
Funding Agency and Grant Number
Corresponding Author Hong-Guo Zhao, MD, Chief Doctor, Professor, Department of Hematology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, Shandong Province, China. zhaohongguo6201@163.com
Key Words Acquired aplastic anemia; Bystander insult; Malignant clonal hematopoiesis; Immune surveillance; Antineoplastic; Gut inflammation
Core Tip We previously reported a severe aplastic anemia patient who had gotten an unexpected hematological response to treatment with intermittent gut-cleansing preparations. After his third recurrence, he was prescribed successive treatment with rifampicin, berberine and monthly administered gut-cleansing preparations for 4 mo, and he developed an erythroid proliferative neoplasma and an overwhelming enteropathy. We hereby make an extrapolation that, in a subgroup of aplastic anemia patients, the suppressed normal hematopoiesis may result from the bystander insult that is generated in response to the antigenic products of damaged hematopoietic cells, and may offer a protectively antineoplastic mechanism against malignant proliferation.
Citation Zhao XC, Sun XY, Ju B, Meng FJ, Zhao HG. Acquired aplastic anemia: Is bystander insult to autologous hematopoiesis driven by immune surveillance against malignant cells? World J Stem Cells 2020; 12(11): 1429-1438
Received
2020-02-14 01:10
Peer-Review Started
2020-02-14 01:10
To Make the First Decision
Return for Revision
2020-09-11 20:34
Revised
2020-09-20 08:04
Second Decision
2020-09-25 09:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-25 19:23
Articles in Press
2020-09-25 19:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-10-07 12:59
Typeset the Manuscript
2020-11-19 07:48
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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