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Publication Name World Journal of Hepatology
Manuscript ID 54801
Country/Territory United States
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Geoepidemiologic variation in outcomes of primary sclerosing cholangitis
Manuscript Source Invited Manuscript
All Author List Tej I Mehta, Simcha Weissman, Brian M Fung and James H Tabibian
Funding Agency and Grant Number
Corresponding author James H Tabibian, FACP, MD, PhD, Associate Professor, Division of Gastroenterology, Department of Medicine, UCLA-Olive View Medical Center, Clinical Health Sciences David Geffen School of Medicine at UCLA, 14445 Olive View Dr 2B-182, Sylmar, CA91342, United States. jtabibian@dhs.lacounty.gov
Keywords Cholangiocarcinoma; Inflammatory bowel disease; Liver transplantation; Geography; Biliary tract; Autoimmune
Core Tip There appears to be considerable geoepidemiologic variation in the outcomes of primary sclerosing cholangitis (PSC). Median liver transplantation-free survival in adults with PSC ranges from 14 to 21 years, depending on geographic region. Post-liver transplantation survival for PSC in North America and Europe appears to be nearly twice that found in Asia. The overall average risk of cholangiocarcinoma among patients with PSC is approximately 400 times that of the general population, occurring in roughly 7%-9% of all patients with PSC. However, these rates vary from region to region, with East Asia having rates roughly three-times higher compared to other regions. Studies from North America, Europe, and Oceania generally report worse clinical outcomes for patients with PSC-inflammatory bowel disease compared to patients with only PSC or inflammatory bowel disease; however, this association is less prominent in studies from Asia.
Citation Mehta TI, Weissman S, Fung BM, Tabibian JH. Geoepidemiologic variation in outcomes of primary sclerosing cholangitis. World J Hepatol 2020; In press
Received
2020-02-19 13:19
Peer-Review Started
2020-02-19 13:21
To Make the First Decision
Return for Revision
2020-03-15 01:33
Revised
2020-03-15 23:53
Second Decision
2020-03-20 15:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-24 13:07
Articles in Press
2020-03-24 13:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Le Zhang
Reviewer Code 03261272, 03475479, and 03413692
Editorial Director
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 54801-Review.docx
Answering Reviewers 54801-Answering reviewers.pdf
Audio Core Tip 54801-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 54801-Conflict-of-interest statement.pdf
Copyright License Agreement 54801-Copyright license agreement.pdf
Peer-review Report 54801-Peer-review(s).pdf
Scientific Misconduct Check 54801-Scientific misconduct check.pdf
Scientific Editor Work List 54801-Scientific editor work list.pdf