Publication Name	World Journal of Clinical Cases
Manuscript ID	54879
Country	China

Category	Urology & Nephrology
Manuscript Type	Case Report
Article Title	Gitelman syndrome caused by a rare homozygous mutation in the SLC12A3 gene: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Ri-Zhen Yu and Mao-Sheng Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81700649
Corresponding Author	Mao-Sheng Chen, MD, PhD, Assistant Professor, Doctor, Department of Nephrology Division, Zhejiang Provincial People’s Hospital,People’s Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou 310014, Zhenjiang Province, China. maoshengc@126.com
Key Words	Gitelman syndrome; Hypoaclemia; SLC12A3; Homozygous; Rare mutation; Case report
Core Tip	In this manuscript, we reported a case of a patient with severe hypokalemia and diagnosed with Gitelman syndrome by genome sequencing. We found a relatively unusual homozygous mutation in the SLC12A3 gene, which had been rarely reported previously. Besides, this patient had elevated creatinine, different from general Gitelman syndrome, suggesting some factors, including this kind of mutation, might cause renal impairment.
Citation	Yu RZ, Chen MS. Gitelman syndrome caused by a rare homozygous mutation in the SLC12A3 gene: A case report. World J Clin Cases 2020; 8(18): 4252-4258

Received	2020-02-25 15:13
Peer-Review Started	2020-02-25 15:16
To Make the First Decision
Return for Revision	2020-07-04 01:12
Revised	2020-07-18 16:14
Second Decision	2020-08-13 10:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-08-13 21:18
Articles in Press	2020-08-13 21:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-08-25 05:50
Typeset the Manuscript	2020-09-15 17:02

ISSN	2307-8960 (online)
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