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Articles in Press
5/22/2020 5:18:20 AM | Browse: 110 | Download: 389
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zi-Jian Zhang, Kun-Peng Wang, Jing-Gang Mo, Li Xiong and Yu Wen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81970569 |
| National Natural Science Foundation of China |
81773293 |
| Natural Science Foundation of Hunan Province |
2017SK50121 |
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| Corresponding Author |
Yu Wen, MD, Doctor, Professor, Department of General Surgery, The Second Xiangya Hospital, Central South University, Renming Road No.139, Changsha 410011, Hunan Province, China. wenyu2861@csu.edu.cn |
| Key Words |
Cancer stem cells; Photodynamic therapy; Reactive oxygen species; Photosensitizer; Mitochondrial; Endoplasmic reticulum |
| Core Tip |
Photodynamic therapy (PDT) is an effective and promising cancer treatment. PDT directly produces reactive oxygen species (ROS) through photochemical reactions. In this article, we reviewed the production process of oxygen-dependent exogenous ROS and the possible endogenous ROS generation process after PDT-mediated subcellular organelle stress. The intracellular metabolism of several ROS produced by PDT was analyzed. Given the extremely short half-life and limited diffusion distance of ROS, we explain from the subcellular localization of photosensitizers how PDT affects the characteristics of cancer stem cells through changes in mitochondrial permeability, activation of unfolded protein responses, autophagy and so on. |
| Citation |
Zhang ZJ, Wang KP, Mo JG, Xiong L, Wen Y. Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species. World J Stem Cells 2020; 12(7): 562-584 |
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Received |
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2020-02-26 20:13 |
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Peer-Review Started |
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2020-02-26 20:14 |
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To Make the First Decision |
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Return for Revision |
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2020-04-25 21:41 |
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Revised |
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2020-05-17 17:18 |
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Second Decision |
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2020-05-20 10:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-05-22 05:18 |
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Articles in Press |
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2020-05-22 05:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-05-26 00:08 |
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Typeset the Manuscript |
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2020-07-24 08:46 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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