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5/22/2020 5:18:20 AM | Browse: 16 | Download: 11
Publication Name World Journal of Stem Cells
Manuscript ID 54971
Country/Territory China
Category Oncology
Manuscript Type Review
Article Title Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species
Manuscript Source Invited Manuscript
All Author List Zi-Jian Zhang, Kun-Peng Wang, Jing-Gang Mo, Li Xiong and Yu Wen
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81970569
National Natural Science Foundation of China 81773293
Natural Science Foundation of Hunan Province 2017SK50121
Corresponding author Yu Wen, MD, Doctor, Professor, Department of General Surgery, The Second Xiangya Hospital, Central South University, Renming Road No.139, Changsha 410011, Hunan Province, China. wenyu2861@csu.edu.cn
Keywords Cancer stem cells; Photodynamic therapy; Reactive oxygen species; Photosensitizer; Mitochondrial; Endoplasmic reticulum
Core Tip Photodynamic therapy (PDT) is an effective and promising cancer treatment. PDT directly produces reactive oxygen species (ROS) through photochemical reactions. In this article, we reviewed the production process of oxygen-dependent exogenous ROS and the possible endogenous ROS generation process after PDT-mediated subcellular organelle stress. The intracellular metabolism of several ROS produced by PDT was analyzed. Given the extremely short half-life and limited diffusion distance of ROS, we explain from the subcellular localization of photosensitizers how PDT affects the characteristics of cancer stem cells through changes in mitochondrial permeability, activation of unfolded protein responses, autophagy and so on.
Citation Zhang ZJ, Wang KP, Mo JG, Xiong L, Wen Y. Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species. World J Stem Cells 2020; In press
2020-02-26 20:13
Peer-Review Started
2020-02-26 20:14
To Make the First Decision
Return for Revision
2020-04-25 21:41
2020-05-17 17:18
Second Decision
2020-05-20 10:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-22 05:18
Articles in Press
2020-05-22 05:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-05-26 00:08
Typeset the Manuscript
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jie Wang
Reviewer Code 00693245, and 02524648
Editorial Director
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor Tian-Qi Wang
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 54971-Review_WangTQ.docx
Answering Reviewers 54971-Answering reviewers.pdf
Audio Core Tip 54971-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 54971-Conflict-of-interest statement.pdf
Copyright License Agreement 54971-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54971-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 54971-Language certificate.pdf
Peer-review Report 54971-Peer-review(s).pdf
Scientific Misconduct Check 54971-Scientific misconduct check.pdf
Scientific Editor Work List 54971-Scientific editor work list.pdf