Publication Name	World Journal of Clinical Cases
Manuscript ID	54980
Country	South Korea

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis
Manuscript Source	Invited Manuscript
All Author List	Dai Sik Ko, Yun Hak Kim, Tae Sik Goh and Jung Sub Lee
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea NRF-2020R1C1C1003741 National Research Foundation of Korea NRF-2018R1D1A1B07047666 National Research Foundation of Korea NRF-2017M3C9A6047610 Biomedical Research Institute Research council 2020
Corresponding Author	Tae Sik Goh, MD, PhD, Doctor, Surgeon, Orthopaedic Surgery, Pusan National University Hospital, 179 Gudeok-ro, Busan 49241, South Korea. taesikgoh@gmail.com
Key Words	Adolescent idiopathic scoliosis; Mesenchymal stem cell; Bioinformatics; Transcriptome; Proteome;
Core Tip	Adolescent idiopathic scoliosis (AIS) is a common spinal deformity that occurs in adolescent females. Despite many reports, the pathomechanism of this disease is still unclear. Mesenchymal Stem Cells (MSCs) that differentiate into multiple cell lineages are known to contribute to the initiation and progression of AIS, but the exact role has not been understood yet. In this review, we summarize a series of studies on the role of mesenchymal stem cells, with differential expression levels of gene, RNA, and protein, in the pathogenesis of AIS. Furthermore, we present the future perspectives on the role of MSCs in the clinical outcome of AIS.
Citation	Ko DS, Kim YH, Goh TS, Lee JS. Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis. World J Clin Cases 2020; 8(11): 2102-2110

Received	2020-02-27 02:31
Peer-Review Started	2020-02-27 02:31
To Make the First Decision
Return for Revision	2020-04-29 22:31
Revised	2020-05-13 06:54
Second Decision	2020-05-22 09:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-05-23 00:51
Articles in Press	2020-05-23 00:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-06-02 01:18

ISSN	2307-8960 (online)
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