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Publication Name World Journal of Clinical Cases
Manuscript ID 54980
Country/Territory South Korea
Category Orthopedics
Manuscript Type Minireviews
Article Title Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis
Manuscript Source Invited Manuscript
All Author List Dai Sik Ko, Yun Hak Kim, Tae Sik Goh and Jung Sub Lee
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Foundation of Korea NRF-2020R1C1C1003741
National Research Foundation of Korea NRF-2018R1D1A1B07047666
National Research Foundation of Korea NRF-2017M3C9A6047610
Biomedical Research Institute Research council 2020
Corresponding author Tae Sik Goh, MD, PhD, Doctor, Surgeon, Orthopaedic Surgery, Pusan National University Hospital, 179 Gudeok-ro, Busan 49241, South Korea. taesikgoh@gmail.com
Keywords Adolescent idiopathic scoliosis; Mesenchymal stem cell; Bioinformatics; Transcriptome; Proteome
Core Tip Adolescent idiopathic scoliosis (AIS) is a common spinal deformity that occurs in adolescent females. Despite many reports, the pathomechanism of this disease is still unclear. Mesenchymal Stem Cells (MSCs) that differentiate into multiple cell lineages are known to contribute to the initiation and progression of AIS, but the exact role has not been understood yet. In this review, we summarize a series of studies on the role of mesenchymal stem cells, with differential expression levels of gene, RNA, and protein, in the pathogenesis of AIS. Furthermore, we present the future perspectives on the role of MSCs in the clinical outcome of AIS.
Citation Ko DS, Kim YH, Goh TS, Lee JS. Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis. World J Clin Cases 2020; In press
2020-02-27 02:31
Peer-Review Started
2020-02-27 02:31
To Make the First Decision
Return for Revision
2020-04-29 22:31
2020-05-13 06:54
Second Decision
2020-05-22 09:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-23 00:51
Articles in Press
2020-05-23 00:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jie Wang
Reviewer Code 03808952
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 54980-Review.docx
Answering Reviewers 54980-Answering reviewers.pdf
Audio Core Tip 54980-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 54980-Conflict-of-interest statement.pdf
Copyright License Agreement 54980-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54980-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 54980-Language certificate.pdf
Peer-review Report 54980-Peer-review(s).pdf
Scientific Misconduct Check 54980-Scientific misconduct check.pdf
Scientific Editor Work List 54980-Scientific editor work list.pdf