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6/27/2020 8:52:07 PM | Browse: 30 | Download: 13
Publication Name World Journal of Stem Cells
Manuscript ID 55168
Country/Territory China
Category Medicine, Research and Experimental
Manuscript Type Review
Article Title Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine
Manuscript Source Invited Manuscript
All Author List Zhan-Jun Ma, Jing-Jing Yang, Yu-Bao Lu, Zhao-Yang Liu and Xue-Xi Wang
Funding Agency and Grant Number
Funding Agency Grant Number
Chinese Medicine Administration Research Project of Gansu province GZK-2019-46
Cuiying Technology Innovation Project of Lanzhou University Second Hospital CY2019-MS10
Corresponding author Xue-Xi Wang, MD, Professor, School of Basic Medical Sciences, Lanzhou University, School of Medicine 205 Tianshui Rd South Lanzhou, Lanzhou 730000, Gansu Province, China. wangxuexi@lzu.edu.cn
Keywords Exosomes; Mesenchymal stem cells; Cell-free therapy; Regenerative medicine; Mesenchymal stem cell-derived exosomes; Extracellular vesicles
Core Tip Mesenchymal stem cell-derived exosomes (MSC-Exos) contain a variety of functional proteins, mRNAs, miRNAs, and signaling lipids. MSC-Exos are more stable than their parent cells and do not have the safety issues of living cells, such as tumorigenesis and occlusion of the microvasculature. MSC-Exos represent an alternative to MSC-based therapies for regenerative medicine. In this review, we summarize the characteristics of MSC-Exos and highlight their functions and therapeutic potential for tissue/organ regeneration and for kidney, liver, cardiovascular, neurological, and musculoskeletal diseases, as well as cutaneous wound healing.
Citation Ma ZJ, Yang JJ, Lu YB, Liu ZY, Wang XY. Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine. World J Stem Cells 2020; In press
Received
2020-03-15 09:46
Peer-Review Started
2020-03-15 09:47
To Make the First Decision
Return for Revision
2020-04-07 22:56
Revised
2020-04-23 10:50
Second Decision
2020-06-22 09:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-06-27 20:52
Articles in Press
2020-06-27 20:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-07-03 02:24
Typeset the Manuscript
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ying Dou
Reviewer Code 03472014, 00505755, and 00504800
Editorial Director
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor Tian-Qi Wang
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 55168-Review_WangTQ.doc
Answering Reviewers 55168-Answering reviewers.pdf
Audio Core Tip 55168-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 55168-Conflict-of-interest statement.pdf
Copyright License Agreement 55168-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 55168-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 55168-Language certificate.pdf
Peer-review Report 55168-Peer-review(s).pdf
Scientific Misconduct Check 55168-Bing-Tang JZ-1.png
Scientific Misconduct Check 55168-Bing-Dou Y-2.png
Scientific Misconduct Check 55168-Scientific misconduct check.pdf
Scientific Editor Work List 55168-Scientific editor work list.pdf