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Publication Name World Journal of Gastroenterology
Manuscript ID 55430
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients
Manuscript Source Unsolicited Manuscript
All Author List Na-Ling Kang, Jie-Min Zhang, Meng-Xin Lin, Xu-Dong Chen, Zu-Xiong Huang, Yue-Yong Zhu, Yu-Rui Liu and Da-Wu Zeng
Funding Agency and Grant Number
Funding Agency Grant Number
Science and Technology Department of Fujian Province 2018J01164
Quanzhou Science and Technology Bureau Planning Project 2019N019S
Corresponding author Da-Wu Zeng, MD, PhD, Associate Chief Physician, Doctor, Liver Center, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. zengdw1980@fjmu.edu.cn
Keywords Ceruloplasmin; Liver fibrosis; Chronic hepatitis B infection; Serum alanine aminotransferase; Noninvasive model; Receiver-operating characteristic
Core Tip Chronic hepatitis B virus (HBV)-infected individuals with persistently normal serum alanine aminotransferase levels (PNALT) may develop severe liver fibrosis, which requires antiviral therapy. Following up on our previous findings, this multicenter, cross-sectional study showed that ceruloplasmin (CP) has an inverse correlation with liver fibrosis and is a promising predictive marker for liver fibrosis among HBV-infected individuals with PNALT. We developed a noninvasive model using CP, platelet, and HBsAg levels to identify the various stages of fibrosis among HBV-infected individuals with PNALT. Our model could reduce the need for liver biopsy before antiviral treatment.
Citation Kang NL, Zhang JM, Lin MX, Chen XD, Huang ZX, Zhu YY, Liu YR, Zeng DW. Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients. World J Gastroenterol 2020; In press
2020-03-17 12:07
Peer-Review Started
2020-03-17 12:07
To Make the First Decision
Return for Revision
2020-04-25 05:41
2020-05-06 14:30
Second Decision
2020-06-29 10:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-06-29 22:31
Articles in Press
2020-06-29 22:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-07-03 02:21
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ying Dou
Reviewer Code 03721496, 02441021, 03536939, 03536939, and 02441021
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 55430-Review_WangTQ.docx
Answering Reviewers 55430-Answering reviewers.pdf
Audio Core Tip 55430-Audio core tip.m4a
Biostatistics Review Certificate 55430-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 55430-Conflict-of-interest statement.pdf
Copyright License Agreement 55430-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 55430-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 55430-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 55430-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 55430-Language certificate.pdf
Supplementary Material 55430-Supplementary material.pdf
Peer-review Report 55430-Peer-review(s).pdf
Scientific Misconduct Check 55430-Bing-Dou Y-2.png
Scientific Misconduct Check 55430-Scientific misconduct check.pdf
Scientific Editor Work List 55430-Scientific editor work list.pdf