Publication Name	World Journal of Gastroenterology
Manuscript ID	55430
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients
Manuscript Source	Unsolicited Manuscript
All Author List	Na-Ling Kang, Jie-Min Zhang, Meng-Xin Lin, Xu-Dong Chen, Zu-Xiong Huang, Yue-Yong Zhu, Yu-Rui Liu and Da-Wu Zeng
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Department of Fujian Province 2018J01164 Quanzhou Science and Technology Bureau Planning Project 2019N019S
Corresponding Author	Da-Wu Zeng, MD, PhD, Associate Chief Physician, Doctor, Liver Center, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. zengdw1980@fjmu.edu.cn
Key Words	Ceruloplasmin; Liver fibrosis; Chronic hepatitis B infection; Serum alanine aminotransferase; Noninvasive model; Receiver-operating characteristic
Core Tip	Chronic hepatitis B virus (HBV)-infected individuals with persistently normal serum alanine aminotransferase levels (PNALT) may develop severe liver fibrosis, which requires antiviral therapy. Following up on our previous findings, this multicenter, cross-sectional study showed that ceruloplasmin (CP) has an inverse correlation with liver fibrosis and is a promising predictive marker for liver fibrosis among HBV-infected individuals with PNALT. We developed a noninvasive model using CP, platelet, and HBsAg levels to identify the various stages of fibrosis among HBV-infected individuals with PNALT. Our model could reduce the need for liver biopsy before antiviral treatment.
Citation	Kang NL, Zhang JM, Lin MX, Chen XD, Huang ZX, Zhu YY, Liu YR, Zeng DW. Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients. World J Gastroenterol 2020; 26(27): 3952-3962

Received	2020-03-17 12:07
Peer-Review Started	2020-03-17 12:07
To Make the First Decision
Return for Revision	2020-04-25 05:41
Revised	2020-05-06 14:30
Second Decision	2020-06-29 10:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-06-29 22:31
Articles in Press	2020-06-29 22:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-07-03 02:21
Typeset the Manuscript	2020-07-20 06:59

ISSN	1007-9327 (print) and 2219-2840 (online)
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