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9/15/2020 11:46:48 PM | Browse: 20 | Download: 18
Publication Name World Journal of Gastroenterology
Manuscript ID 55794
Country/Territory United States
Category Gastroenterology and Hepatology
Manuscript Type Opinion Review
Article Title Role of betaine in liver disease-worth revisiting or has the die been cast?
Manuscript Source Invited Manuscript
All Author List Sandeep Mukherjee
Funding Agency and Grant Number
Corresponding author Sandeep Mukherjee, FRCP (C), MBChB, Full Professor, Department of Medicine, Creighton University Medical Center, Division of Gastroenterology, Education Building, Suite 401 7710 Mercy Road, Omaha, NE 68124, United States. sandeep.mukherjee@alegent.org
Key Words Betaine; Obesity; Insulin resistance; Nonalcoholic steatohepatitis; Cirrhosis; S-adenosyl homocysteine; S-adenosyl methionine
Core Tip This article revisits the role of betaine in liver disease with a focus on nonalcoholic steatohepatitis. Although a randomized controlled trial did not report benefit over placebo, there were limitations with the study. Given the excellent safety profile and tolerance of betaine, it appears this would be an appropriate time to re-evaluate betaine for liver diseases such as nonalcoholic and alcoholic liver diseases.
Citation Mukherjee S. Role of betaine in liver disease-worth revisiting or has the die been cast? World J Gastroenterol 2020; In press
Received
2020-05-21 06:24
Peer-Review Started
2020-05-21 06:25
To Make the First Decision
Return for Revision
2020-05-29 03:38
Revised
2020-08-25 09:16
Second Decision
2020-09-15 11:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-15 23:46
Articles in Press
2020-09-15 23:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Pan Huang
Reviewer Code 00199807, and 00199807
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 55794-Review.docx
Answering Reviewers 55794-Answering reviewers.pdf
Audio Core Tip 55794-Audio core tip.wav
Conflict-of-Interest Disclosure Form 55794-Conflict-of-interest statement.pdf
Copyright License Agreement 55794-Copyright license agreement.pdf
Peer-review Report 55794-Peer-review(s).pdf
Scientific Misconduct Check 55794-Bing-Yang Y-1.png
Scientific Misconduct Check 55794-Scientific misconduct check.pdf
Scientific Editor Work List 55794-Scientific editor work list.pdf