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9/16/2020 12:04:32 AM | Browse: 36 | Download: 32
Publication Name World Journal of Clinical Cases
Manuscript ID 56287
Country/Territory China
Category Infectious Diseases
Manuscript Type Retrospective Study
Article Title High serum lactate dehydrogenase and dyspnea: Positive predictors for adverse event with critical COVID-19 patients in Yichang
Manuscript Source Invited Manuscript
All Author List Xiao-Ting Lv, Yong-Ping Zhu, Ai-Guo Cheng, Yong-Xu Jin, Hai-Bo Ding, Cai-Yun Wang, Shu-Yu Zhang, Gong-Ping Chen, Qing-Quan Chen and Qi-Cai Liu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81800070
Development Fund Program of Fujian Provincial Health and Family Planning Commission 2017-1-43
Corresponding author Qi-Cai Liu, MD, Chief Technician, Doctor, Teacher, Department of Reproductive Medicine Centre, First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. lqc673673673@163.com
Key Words COVID-19; SARS-CoV-2; Lactate dehydrogenase; Pulmonary fibrosis; Dyspnea; Overall survival
Core Tip We explored the serum lactate dehydrogenase (LDH) and clinical characteristics in critical coronavirus disease 2019 (COVID-19) patients and its predictive value for prognosis. We retrospective evaluated 47 critical COVID-19 patients and divided them into non-survivors and survivors groups. Clinical data including symptoms, detection of severe acute respiratory syndrome coronavirus 2, chest computed tomography images, changes of serum LDH in different clinical phases, and prognosis was collected. In our study, high LDH was obviously positively correlated with worsening overall survival. High LDH and dyspnea symptom were positive predictors for adverse event in critical COVID-19 patients. The rapid progressive fibrosis stage may be more perilous than alveolitis stage, even if severe acute respiratory syndrome coronavirus 2 was undetectable.
Citation Lv XT, Zhu YP, Cheng AG, Jin YX, Ding HB, Wang CY, Zhang SY, Chen GP, Chen QQ, Liu QC. High serum lactate dehydrogenase and dyspnea: Positive predictors for adverse event with critical COVID-19 patients in Yichang. World J Clin Cases 2020; In press
Received
2020-04-26 17:11
Peer-Review Started
2020-04-26 17:12
To Make the First Decision
Return for Revision
2020-08-23 01:07
Revised
2020-09-04 11:07
Second Decision
2020-09-15 11:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-16 00:04
Articles in Press
2020-09-16 00:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Le Zhang
Reviewer Code 05378509, 02505244, and 05378509
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 56287-Review.docx
Answering Reviewers 56287-Answering reviewers.pdf
Audio Core Tip 56287-Audio core tip.mp3
Biostatistics Review Certificate 56287-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 56287-Conflict-of-interest statement.pdf
Copyright License Agreement 56287-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 56287-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 56287-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 56287-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 56287-Language certificate.pdf
Peer-review Report 56287-Peer-review(s).pdf
Scientific Misconduct Check 56287-Scientific misconduct check.pdf
Scientific Editor Work List 56287-Scientific editor work list.pdf