Publication Name	World Journal of Clinical Cases
Manuscript ID	56287
Country	China

Category	Infectious Diseases
Manuscript Type	Retrospective Study
Article Title	High serum lactate dehydrogenase and dyspnea: Positive predictors for adverse event with critical COVID-19 patients in Yichang
Manuscript Source	Invited Manuscript
All Author List	Xiao-Ting Lv, Yong-Ping Zhu, Ai-Guo Cheng, Yong-Xu Jin, Hai-Bo Ding, Cai-Yun Wang, Shu-Yu Zhang, Gong-Ping Chen, Qing-Quan Chen and Qi-Cai Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81800070 Development Fund Program of Fujian Provincial Health and Family Planning Commission 2017-1-43
Corresponding Author	Qi-Cai Liu, MD, Chief Technician, Doctor, Teacher, Department of Reproductive Medicine Centre, First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. lqc673673673@163.com
Key Words	COVID-19; SARS-CoV-2; Lactate dehydrogenase; Pulmonary fibrosis; Dyspnea; Overall survival
Core Tip	We explored the serum lactate dehydrogenase (LDH) and clinical characteristics in critical coronavirus disease 2019 (COVID-19) patients and its predictive value for prognosis. We retrospective evaluated 47 critical COVID-19 patients and divided them into non-survivors and survivors groups. Clinical data including symptoms, detection of severe acute respiratory syndrome coronavirus 2, chest computed tomography images, changes of serum LDH in different clinical phases, and prognosis was collected. In our study, high LDH was obviously positively correlated with worsening overall survival. High LDH and dyspnea symptom were positive predictors for adverse event in critical COVID-19 patients. The rapid progressive fibrosis stage may be more perilous than alveolitis stage, even if severe acute respiratory syndrome coronavirus 2 was undetectable.
Citation	Lv XT, Zhu YP, Cheng AG, Jin YX, Ding HB, Wang CY, Zhang SY, Chen GP, Chen QQ, Liu QC. High serum lactate dehydrogenase and dyspnea: Positive predictors for adverse event with critical COVID-19 patients in Yichang. World J Clin Cases 2020; 8(22): 5535-5546

Received	2020-04-26 17:11
Peer-Review Started	2020-04-26 17:12
To Make the First Decision
Return for Revision	2020-08-23 01:07
Revised	2020-09-04 11:07
Second Decision	2020-09-15 11:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-09-16 00:04
Articles in Press	2020-09-16 00:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-10-10 06:57
Typeset the Manuscript	2020-11-21 05:32

ISSN	2307-8960 (online)
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