Publication Name	World Journal of Gastroenterology
Manuscript ID	56428
Country	Mexico

Category	Research & Experimental Medicine
Manuscript Type	Observational Study
Article Title	Experimental model standardizing polyvinyl alcohol hydrogel to simulate endoscopic ultrasound and endoscopic ultrasound-elastography
Manuscript Source	Unsolicited Manuscript
All Author List	Elymir S Galvis-García, Sergio Sobrino-Cossío, Arturo Reding-Bernal, Yesica Contreras-Marín, Karina Solórzano-Acevedo, Patricia González-Zavala and Rosa M Quispe-Siccha
Funding Agency and Grant Number
Corresponding Author	Rosa M Quispe-Siccha, PhD, Academic Research, Research Scientist, Unidad de Investigación y Desarrollo Tecnológico , Hospital General de México "Dr. Eduardo Liceaga", Dr. Balmis 148, Doctores, Cuauhtémoc, Mexico 06720, Mexico. rosa.quispe@gmail.com
Key Words	Endoscopic ultrasound simulators in endoscopy; Polyvinyl alcohol; Endoscopic ultrasound; Endoscopic ultrasound elastography; Strain; Elasticity
Core Tip	Endoscopic ultrasound (EUS)/EUS-elastography simulation reduces the learning curve. In this study, the mechanical properties of polyvinyl alcohol hydrogel were standardized to simulate digestive organs and lesions. Polyvinyl alcohol hydrogel (PVA)-hydrogels with stable mechanical properties were obtained; the density depended on the molecular weight (MW) and its concentration (C), the PVA-hydrogels with the highest density showed less tensile strength. All lesions were visible by EUS/EUS-Elastography; those that were homogeneous and heterogeneous were created with hydrogels of higher density (MW2, C9 and C10) and lower (MW1, C1 and C2), respectively. In conclusion, PVA-hydrogels are appropriate for simulating organs and digestive lesions, facilitating practice and reducing risk.
Citation	Galvis-García ES, Sobrino-Cossío S, Reding-Bernal A, Contreras-Marín Y, Solórzano-Acevedo K, González-Zavala P, Quispe-Siccha RM. Experimental model standardizing polyvinyl alcohol hydrogel to simulate endoscopic ultrasound and endoscopic ultrasound-elastography. World J Gastroenterol 2020; 26(34): 5169-5180

Received	2020-04-30 20:00
Peer-Review Started	2020-04-30 20:01
To Make the First Decision
Return for Revision	2020-05-15 21:21
Revised	2020-07-27 18:44
Second Decision	2020-08-14 09:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-08-14 16:51
Articles in Press	2020-08-14 16:51
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-08-25 05:50
Typeset the Manuscript	2020-09-09 00:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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