Publication Name	World Journal of Gastroenterology
Manuscript ID	56819
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Acupuncture improved lipid metabolism by regulating intestinal absorption in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Jia Han, Xin Guo, Xiang-Jin Meng, Jing Zhang, Reimon Yamaguchi, Yoshiharu Motoo and Sohsuke Yamada
Funding Agency and Grant Number	Funding Agency Grant Number Grants-in-Aid for Scientific Research 19K16783 Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan 20K07454,20K17363 Grant for Promoted Research from Kanazawa Medical University S2018-6
Corresponding Author	Xin Guo, PhD, Doctor, Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan. tianqi11211216@yahoo.co.jp
Key Words	Acupuncture; Non-alcoholic fatty liver disease; Small intestine; Lipid metabolism; Apolipoproteins;
Core Tip	In the present study, our experimental data showed that acupuncture treatment suppressed high-fat-induced body weight gain, reduced the accumulation of intra-abdominal fat, inhibited lipid absorption in the small intestine and downregulated the blood lipid level in mice with non-alcoholic fatty liver disease, suggesting that acupuncture potentially had variable beneficial effects in improving the lipid metabolism in the presence of abnormal liver metabolism. Furthermore, we also found more fat deposition in the intestinal epithelium with the decreased expression of some intestinal apolipoproteins in acupuncture-treated mice, suggesting that acupuncture may suppress lipid absorption by downregulating the expression of apolipoproteins in the small intestine.
Citation	Han J, Guo X, Meng XJ, Zhang J, Yamaguchi R, Motoo Y, Yamada S. Acupuncture improved lipid metabolism by regulating intestinal absorption in mice. World J Gastroenterol 2020; 26(34): 5118-5129

Received	2020-05-19 09:32
Peer-Review Started	2020-05-19 09:33
To Make the First Decision
Return for Revision	2020-06-20 00:27
Revised	2020-06-30 02:46
Second Decision	2020-08-13 11:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-08-13 21:13
Articles in Press	2020-08-13 21:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-09-09 00:56

ISSN	1007-9327 (print) and 2219-2840 (online)
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