Publication Name	World Journal of Stem Cells
Manuscript ID	56871
Country	United States

Category	Oncology
Manuscript Type	Therapeutic and Diagnostic Guidelines
Article Title	Hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective
Manuscript Source	Invited Manuscript
All Author List	Lisa X Lee and Shengwen Calvin Li
Funding Agency and Grant Number
Corresponding Author	Shengwen Calvin Li, PhD, Professor, Neuro-oncology and Stem Cell Research Laboratory, CHOC Children's Research Institute, Children's Hospital of Orange County, 1201 W La Veta Ave., Orange, CA 92868, United States. shengwel@uci.edu
Key Words	Multiple myeloma; Single cells; Single-cell transcriptome; Subclonal evolution; Cancer stem cells; Systemic tracking of single-cell landscape
Core Tip	Current methods for determining prognosis in multiple myeloma are limited. The prototype device called Multi-Phase Laser-cavitation Single Cell Analyzer can perform reverse transcriptase polymerase chain reaction (RT-PCR) on single cells in a one-step microfluidics chip platform. The ability of the microfluidics chip platform to enrich plasma cell content by depleting CD45+ white blood cells has been demonstrated. Further studies will need to combine single-cell selection with RT-PCR to further enhance the diagnostic capabilities of this technology. This platform has the potential to be used for clinical risk stratification in multiple myeloma as well as minimal residual disease monitoring and selection of therapies to modulate the development of resistance.
Citation	Lee LX, Li SC. Hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective. World J Stem Cells 2020; 12(8): 706-720

Received	2020-05-18 06:35
Peer-Review Started	2020-05-18 06:36
To Make the First Decision
Return for Revision	2020-06-05 18:46
Revised	2020-07-08 09:45
Second Decision	2020-08-13 11:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-08-13 21:19
Articles in Press	2020-08-13 21:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-08-25 06:40

ISSN	1948-0210 (online)
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