Publication Name	World Journal of Gastroenterology
Manuscript ID	56881
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Eun Ae Kang, Jaeyoung Chun, Jee Hyun Kim, Kyungdo Han, Hosim Soh, Seona Park, Seung Wook Hong, Jung Min Moon, Jooyoung Lee, Hyun Jung Lee, Jun-Beom Park, Jong Pil Im and Joo Sung Kim
Funding Agency and Grant Number
Corresponding Author	Jaeyoung Chun, MD, Assistant Professor, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Yeonju-ro 63-gil, Gangnam-gu, Seoul 06229, South Korea. chunjmd@yuhs.ac
Key Words	Inflammatory bowel disease; Periodontitis; Smoking; Ulcerative colitis; Crohn’s disease;
Core Tip	We evaluate the impact of periodontitis on the development of ulcerative colitis (UC) using the nationwide population-based cohort data. In total, 9950548 individuals undergoing national health screenings in 2009 were included in this study and were followed for an average of 7.26 years. Patients with periodontitis had a higher risk of UC than those without periodontitis. Current smokers over 65 years with periodontitis were at a 1.9-fold increased risk of UC than non-smokers without periodontitis. Periodontitis was significantly associated with the risk of UC and cigarette smoking could superimpose the impact of periodontitis on UC, especially in elderly people.
Citation	Kang EA, Chun J, Kim JH, Han K, Soh H, Park S, Hong SW, Moon JM, Lee J, Lee HJ, Park JB, Im JP, Kim JS. Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study. World J Gastroenterol 2020; 26(37): 5661-5672

Received	2020-05-18 13:47
Peer-Review Started	2020-05-18 13:48
To Make the First Decision
Return for Revision	2020-07-29 05:05
Revised	2020-08-07 10:15
Second Decision	2020-09-15 11:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-09-15 23:47
Articles in Press	2020-09-15 23:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-09-25 06:47

ISSN	1007-9327 (print) and 2219-2840 (online)
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