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Publication Name World Journal of Gastroenterology
Manuscript ID 57052
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Development of a novel score for the diagnosis of bacterial infection in patients with acute-on-chronic liver failure
Manuscript Source Invited Manuscript
All Author List Su Lin, Yan-Yan Yan, Yin-Lian Wu, Ming-Fang Wang, Yue-Yong Zhu and Xiao-Zhong Wang
Funding Agency and Grant Number
Funding Agency Grant Number
Chinese National Science and Technology Projects 2017ZX10202201
Corresponding author Xiao-Zhong Wang, MD, PhD, Chief Doctor, Department of Gastroenterology, Union Hospital of Fujian Medical University, No. 29, Shengmiao Road, Gulou, Fuzhou 350000, Fujian Province, China. drwangxz@163.com
Keywords Acute on chronic liver failure; Bacterial infection; Score
Core Tip This is a retrospective study to evaluate the diagnostic value of widely used biomarkers for infection, including procalcitonin (PCT), white blood cell, proportion of neutrophils (N%), and C-reactive protein (CRP) for bacterial infection in ACLF. The results showed that all of the four parameters did not perform well in ACLF, with no significant difference being found among them. Then we developed a novel scoring system comprised of N%, PCT and CRP which demonstrated a higher accuracy for bacterial infection in ACLF than the indicators used alone. Further validation of this scoring system is required in prospective studies.
Citation Lin S, Yan YY, Wu YL, Wang MF, Zhu YY, Wang XZ. Development of a novel score for the diagnosis of bacterial infection in patients with acute-on-chronic liver failure. World J Gastroenterol 2020; In press
Received
2020-05-23 21:00
Peer-Review Started
2020-05-23 21:01
To Make the First Decision
Return for Revision
2020-06-12 23:35
Revised
2020-06-18 17:55
Second Decision
2020-07-28 12:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-07-30 05:18
Articles in Press
2020-07-30 05:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-08-04 06:37
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ping Yan
Reviewer Code 02441021
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor J Webster
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 57052-Review-Webster J.docx
Answering Reviewers 57052-Answering reviewers.pdf
Audio Core Tip 57052-Audio core tip.m4a
Biostatistics Review Certificate 57052-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 57052-Conflict-of-interest statement.pdf
Copyright License Agreement 57052-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 57052-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 57052-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 57052-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 57052-Language certificate.pdf
Peer-review Report 57052-Peer-review(s).pdf
Scientific Misconduct Check 57052-Bing-Yan JP-1.png
Scientific Misconduct Check 57052-Bing-Yan JP-2.png
Scientific Misconduct Check 57052-Scientific misconduct check.pdf
Scientific Editor Work List 57052-Scientific editor work list.pdf