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Publication Name World Journal of Gastroenterology
Manuscript ID 57052
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Development of a novel score for the diagnosis of bacterial infection in patients with acute-on-chronic liver failure
Manuscript Source Invited Manuscript
All Author List Su Lin, Yan-Yan Yan, Yin-Lian Wu, Ming-Fang Wang, Yue-Yong Zhu and Xiao-Zhong Wang
Funding Agency and Grant Number
Funding Agency Grant Number
Chinese National Science and Technology Projects 2017ZX10202201
Corresponding Author Xiao-Zhong Wang, MD, PhD, Chief Doctor, Department of Gastroenterology, Union Hospital of Fujian Medical University, No. 29, Shengmiao Road, Gulou, Fuzhou 350000, Fujian Province, China. drwangxz@163.com
Key Words Acute on chronic liver failure; Bacterial infection; Score; ; ;
Core Tip This is a retrospective study to evaluate the diagnostic value of widely used biomarkers for infection, including procalcitonin (PCT), white blood cell, proportion of neutrophils (N%), and C-reactive protein (CRP) for bacterial infection in ACLF. The results showed that all of the four parameters did not perform well in ACLF, with no significant difference being found among them. Then we developed a novel scoring system comprised of N%, PCT and CRP which demonstrated a higher accuracy for bacterial infection in ACLF than the indicators used alone. Further validation of this scoring system is required in prospective studies.
Citation Lin S, Yan YY, Wu YL, Wang MF, Zhu YY, Wang XZ. Development of a novel score for the diagnosis of bacterial infection in patients with acute-on-chronic liver failure. World J Gastroenterol 2020; 26(32): 4857-4865
Received
2020-05-23 21:00
Peer-Review Started
2020-05-23 21:01
To Make the First Decision
Return for Revision
2020-06-12 23:35
Revised
2020-06-18 17:55
Second Decision
2020-07-28 12:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-07-30 05:18
Articles in Press
2020-07-30 05:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-08-04 06:37
Typeset the Manuscript
2020-08-19 22:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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