Publication Name	World Journal of Gastroenterology
Manuscript ID	57087
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Liver fat accumulation measured by high-speed T2-corrected multi-echo magnetic resonance spectroscopy can predict risk of cholelithiasis
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Chen, Wei-Ke Zeng, Guang-Zi Shi, Ming Gao, Meng-Zhu Wang and Jun Shen
Funding Agency and Grant Number
Corresponding Author	Jun Shen, MD, Doctor, Professor, Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107, Yanjiang Road West, Guangzhou 510120, Guangdong Province, China. shenjun@mail.sysu.edu.cn
Key Words	Magnetic resonance spectroscopy; Cholelithiasis; Liver fat accumulation; Steatosis; Iron;
Core Tip	The increase in total cholesterol synthesis can cause tissues to be overloaded with fatty acids, resulting in more lithogenic bile due to overproduction of hepatic cholesterol. Our study showed that patients with cholelithiasis had higher liver fat content and R2 value as assessed by high speed T2-corrected multi-echo magnetic resonance spectroscopy (MRS). MRS can be used for quantitative detection of mild liver steatosis, and proton density fat fraction (PDFF) derived from MRS can predict the risk of cholelithiasis. PDFF measured by MRS can quantitatively detect liver steatosis in a simple breath-hold of 15 s, which holds a good potential for clinical application.
Citation	Chen H, Zeng WK, Shi GZ, Gao M, Wang MZ, Shen J. Liver fat accumulation measured by high-speed T2-corrected multi-echo magnetic resonance spectroscopy can predict risk of cholelithiasis. World J Gastroenterol 2020; 26(33): 4996-5007

Received	2020-05-29 17:02
Peer-Review Started	2020-05-29 17:03
To Make the First Decision
Return for Revision	2020-06-12 18:08
Revised	2020-06-14 13:14
Second Decision	2020-07-31 09:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-08-01 05:47
Articles in Press	2020-08-01 05:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-08-07 02:01
Typeset the Manuscript	2020-08-24 00:53

ISSN	1007-9327 (print) and 2219-2840 (online)
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