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Publication Name World Journal of Gastroenterology
Manuscript ID 57087
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Liver fat accumulation measured by high-speed T2-corrected multi-echo magnetic resonance spectroscopy can predict the risk of cholelithiasis
Manuscript Source Unsolicited Manuscript
All Author List Hong Chen, Wei-Ke Zeng, Guang-Zi Shi, Ming Gao, Meng-Zhu Wang and Jun Shen
Funding Agency and Grant Number
Corresponding author Jun Shen, MD, Doctor, Professor, Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107, Yanjiang Road West, Guangzhou 510120, Guangdong Province, China. shenjun@mail.sysu.edu.cn
Keywords Magnetic resonance spectroscopy; Cholelithiasis; Liver fat accumulation; Steatosis; Iron
Core Tip The increase in total cholesterol synthesis can cause tissues to be overloaded with fatty acids, resulting in more lithogenic bile due to overproduction of hepatic cholesterol. Our study showed that patients with cholelithiasis had higher liver fat content and R2 value as assessed by high speed T2-corrected multi-echo magnetic resonance spectroscopy (MRS). MRS can be used for quantitative detection of mild liver steatosis, and proton density fat fraction (PDFF) derived from MRS can predict the risk of cholelithiasis. PDFF measured by MRS can quantitatively detect liver steatosis in a simple breath-hold of 15 s, which holds a good potential for clinical application.
Citation Chen H, Zeng WK, Shi GZ, Gao M, Wang MZ, Shen J. Liver fat accumulation measured by high-speed T2-corrected multi-echo magnetic resonance spectroscopy can predict the risk of cholelithiasis. World J Gastroenterol 2020; In press
Received
2020-05-29 17:02
Peer-Review Started
2020-05-29 17:03
To Make the First Decision
Return for Revision
2020-06-12 18:08
Revised
2020-06-14 13:14
Second Decision
2020-07-31 09:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-08-01 05:47
Articles in Press
2020-08-01 05:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ping Yan
Reviewer Code 02818262, and 02818262
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 57087-Review.docx
Answering Reviewers 57087-Answering reviewers.pdf
Audio Core Tip 57087-Audio core tip.m4a
Biostatistics Review Certificate 57087-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 57087-Conflict-of-interest statement.pdf
Copyright License Agreement 57087-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 57087-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 57087-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 57087-Language certificate.pdf
Peer-review Report 57087-Peer-review(s).pdf
Scientific Misconduct Check 57087-Bing-Yan JP-1.png
Scientific Misconduct Check 57087-Bing-Yan JP-2.png
Scientific Misconduct Check 57087-Scientific misconduct check.pdf
Scientific Editor Work List 57087-Scientific editor work list.pdf