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Publication Name World Journal of Hepatology
Manuscript ID 57110
Country/Territory Spain
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Tumor necrosis family receptor superfamily member 9/tumor necrosis factor receptor-associated factor 1 pathway on hepatitis C viral persistence and natural history
Manuscript Source Invited Manuscript
All Author List Julia Peña-Asensio, Eduardo Sanz-de-Villalobos, Joaquín Miquel and Juan Ramón Larrubia
Funding Agency and Grant Number
Funding Agency Grant Number
Instituto de Salud Carlos III and European Structural Funds in Spain; European Regional Development Fund PI19/00206
Corresponding Author Juan Ramón Larrubia, MD, MSc, PhD, Senior Lecturer, Staff Physician, Translational Hepatology Unit, Guadalajara University Hospital, University of Alcalá, Donante de Sangre St, Guadalajara E-19002, Guadalajara, Spain. juan.larrubia@uah.es
Key Words Hepatitis C virus; Tumor necrosis factor receptor-associated factor 1; CD8; Exhaustion; Tumor necrosis family receptor superfamily member 9; Chronic hepatitis
Core Tip Tumor necrosis factor receptor-associated factor 1 (TRAF1) is the signal transducer of the positive checkpoint tumor necrosis family receptor superfamily member 9 (4-1BB), essential in the activation of adaptive immune response. During persistent hepatitis C virus (HCV) infection, this transducer is down-regulated via transforming growth factor beta 1, linked to T cell exhaustion. Interleukin-7 can restore TRAF1 expression and improve T cell reactivity but only in patients with mild evolution, while cases with a more aggressive progression also need the modulation of other negative co-stimulatory molecules. Therefore, TRAF1 dynamics defines a new pathogenic model that explains the different level of T cell exhaustion and progression during HCV infection and supports the rationale for immunotherapeutic strategies in chronic viral infections.
Citation Peña-Asensio J, Sanz-de-Villalobos E, Miquel J, Larrubia JR. Tumor necrosis family receptor superfamily member 9/tumor necrosis factor receptor-associated factor 1 pathway on hepatitis C viral persistence and natural history. World J Hepatol 2020; 12(10): 754-765
Received
2020-06-13 05:34
Peer-Review Started
2020-06-13 05:35
To Make the First Decision
Return for Revision
2020-07-30 23:30
Revised
2020-08-01 17:26
Second Decision
2020-09-25 09:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-25 19:18
Articles in Press
2020-09-25 19:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-10-18 07:59
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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