Publication Name	World Journal of Hepatology
Manuscript ID	57138
Country	Saudi Arabia

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Efficacy and safety of once daily tacrolimus compared to twice daily tacrolimus after liver transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Khalid Ibrahim Bzeizi, Ali Albenmousa, Mohamed Shawkat, Zidan Ahmed, Saleh Alabbad, Waleed Al-Hamoudi, Roberto Troisi and Deiter Broering
Funding Agency and Grant Number
Corresponding Author	Khalid Ibrahim Bzeizi, FRCP, Doctor, Department of Liver Transplantation, King Faisal Specialist Hospital and Research Center, Zahrawi Street, Al Maather, Riyadh 12713, Saudi Arabia. kbzeizi@kfshrc.edu.sa
Key Words	Prolonged release; Tacrolimus; Liver transplantation; Graft rejection; Renal impairment; FK level
Core Tip	Tacrolimus, a calcineurin inhibitor is an important component of the immunosuppressive regimens post liver transplantation. Compliance to immunosuppression treatment generally is important and non-adherence is a major risk factor of graft rejection and loss. Compliance to medication declines over the course of time in patients after liver transplantation due to several factors and this contributes to about 20% of late acute rejection. The efficacy of once daily tacrolimus regimens has been reported in many studies and this systematic review/meta-analysis confirmed the evidence of comparable efficacy and safety of prolonged release tacrolimus to the twice daily immediate release formulation.
Citation	Bzeizi KI, Albenmousa A, Shawkat AM, Ahmed Z, Alabbad S, Alhamoudi W, Troisi R, Broering D. Efficacy and safety of once daily tacrolimus compared to twice daily tacrolimus after liver transplantation. World J Hepatol 2021; 13(3): 375-383

Received	2020-11-05 12:37
Peer-Review Started	2020-11-05 12:37
To Make the First Decision
Return for Revision	2020-11-30 19:16
Revised	2021-01-04 17:13
Second Decision	2021-02-06 07:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-02-18 20:01
Articles in Press	2021-02-18 20:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-03-01 00:22

ISSN	1948-5182 (online)
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