Publication Name	World Journal of Cardiology
Manuscript ID	57249
Country	Japan

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Retrospective Cohort Study
Article Title	Clinical significance of prolonged chest pain in vasospastic angina
Manuscript Source	Invited Manuscript
All Author List	Hiroki Teragawa, Chikage Oshita and Yuichi Orita
Funding Agency and Grant Number
Corresponding Author	Hiroki Teragawa, FACC, FACP, FAHA, MD, PhD, Chief Doctor, Department of Cardiovascular Medicine, JR Hiroshima Hospital, 3-1-36 Futabanosato, Higashi-ku, Hiroshima 732-0057, Hiroshima, Japan. hiroki-teragawa@jrhh.or.jp
Key Words	Acetylcholine; Prolonged angina attacks; Variant angina; Vasospastic angina; Spasm provocation test; Prognosis
Core Tip	We have sometimes experienced patients with vasospastic angina (VSA) who had prolonged chest symptoms (≥ 15 min). We showed that such VSA patients had higher frequencies of other serious symptoms and variant angina as well as higher frequencies of spasm induction by a low dose of acetylcholine, total occlusion due to spasm, focal spasm, and unavoidable use of nitroglycerin in the spasm provocation test (SPT). On the other hand, the frequency of chest symptoms did not influence these findings in the SPT. Prolonged chest symptoms may be related to more severe characteristics of VSA.
Citation	Teragawa H, Oshita C, Orita Y. Clinical significance of prolonged chest pain in vasospastic angina. World J Cardiol 2020; 12(9): 450-459

Received	2020-06-02 13:02
Peer-Review Started	2020-06-01 13:43
To Make the First Decision
Return for Revision	2020-06-15 18:22
Revised	2020-06-28 08:11
Second Decision	2020-09-14 11:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-09-15 17:39
Articles in Press	2020-09-15 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-09-21 00:36

ISSN	1949-8462 (online)
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