Publication Name	World Journal of Gastroenterology
Manuscript ID	57263
Country	Croatia

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Inactive matrix Gla protein is elevated in patients with inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Darko Brnic, Dinko Martinovic, Piero Marin Zivkovic, Daria Tokic, Marino Vilovic, Doris Rusic, Ivana Tadin Hadjina, Christian Libers, Sandro Glumac, Daniela Supe-Domic, Ante Tonkic and Josko Bozic
Funding Agency and Grant Number
Corresponding Author	Josko Bozic, MD, PhD, Associate Professor, Department of Pathophysiology, University of Split School of Medicine, Soltanska 2, Split 21000, Croatia. josko.bozic@mefst.hr
Key Words	Matrix Gla protein; Inflammatory bowel disease; Fecal calprotectin; Ulcerative colitis; Crohn's disease;
Core Tip	Matrix Gla protein is well-established as a protector against vascular calcification. Recent studies pointed to a possible link between Matrix gla protein and inflammatory bowel disease. Our study found significantly higher inactive plasma Matrix Gla protein (MGP) levels in patients with inflammatory bowel disease (IBD) compared to the healthy controls and there were no differences between patients with ulcerative colitis and Crohn’s disease. Furthermore, there was a significant positive correlation between inactive plasma MGP levels with both fecal calprotectin and high sensitivity C-reactive protein levels. These results imply that MGP is somehow involved in complex IBD pathophysiology.
Citation	Brnic D, Martinovic D, Zivkovic PM, Tokic D, Vilovic M, Rusic D, Tadin Hadjina I, Libers C, Glumac S, Supe-Domic D, Tonkic A, Bozic J. Inactive matrix Gla protein is elevated in patients with inflammatory bowel disease. World J Gastroenterol 2020; 26(32): 4866-4877

Received	2020-05-30 22:13
Peer-Review Started	2020-05-30 22:14
To Make the First Decision
Return for Revision	2020-06-12 17:59
Revised	2020-07-30 21:48
Second Decision	2020-08-14 09:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-08-14 16:50
Articles in Press	2020-08-14 16:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-08-28 03:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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