Publication Name	World Journal of Gastroenterology
Manuscript ID	57275
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Feasibility and efficacy evaluation of metallic biliary stents eluting gemcitabine and cisplatin for extrahepatic cholangiocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Bo Xiao, Jun-Yong Weng, Yang-Yang Hu, Gui-Long Deng and Xin-Jian Wan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81470904 Science and Technology Development Funds of Shanghai of China 16411952400 National Natural Science Foundation of China 81870452
Corresponding Author	Xin-Jian Wan, MD, Chief Doctor, Department of Gastroenterology & Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 650, Xinsongjiang Road, Shanghai 201620, China. xinjian_wan_shsl@163.com
Key Words	Extrahepatic cholangiocarcinoma; Drug-eluting stent; Local chemotherapy; Gemcitabine; Cisplatin; Biliary obstruction
Core Tip	Drug-eluting stent is a relatively new therapeutic concept for malignant biliary obstructions; however, there have only been limited studies reported and all of them were single-drug-loaded type with a simple design, also lack complete, serial in vitro and in vivo study. Our study was the first trial to apply dual chemotherapeutic medications to Drug-eluting stent with several improvements in the design compared to previous ones for the palliative therapy of extrahepatic cholangiocarcinoma with relatively complete pre-clinical evaluation, and our results indicated this brand-new stent could be a promising alternative to realize dual functions of biliary drainage and local chemotherapy.
Citation	Xiao JB, Weng JY, Hu YY, Deng GL, Wan XJ. Feasibility and efficacy evaluation of metallic biliary stents eluting gemcitabine and cisplatin for extrahepatic cholangiocarcinoma. World J Gastroenterol 2020; 26(31): 4589-4606

Received	2020-06-03 23:09
Peer-Review Started	2020-06-03 23:09
To Make the First Decision
Return for Revision	2020-06-18 04:36
Revised	2020-06-30 21:27
Second Decision	2020-07-28 12:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-07-30 05:14
Articles in Press	2020-07-30 05:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-08-08 03:21
Typeset the Manuscript	2020-08-20 00:40

ISSN	1007-9327 (print) and 2219-2840 (online)
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