Publication Name	World Journal of Critical Care Medicine
Manuscript ID	57287
Country	India

Category	Critical Care Medicine
Manuscript Type	Prospective Study
Article Title	Multicentered prospective investigator initiated study to evaluate the clinical outcomes with extracorporeal cytokine adsorption device (cytoSorb®) in patients with sepsis and septic shock
Manuscript Source	Unsolicited Manuscript
All Author List	Rajib Paul, Prachee Sathe, Senthil Kumar, Shiva Prasad, Ma Aleem and Prashant Sakhalvalkar
Funding Agency and Grant Number
Corresponding Author	Rajib Paul, DNB, MD, Doctor, Professor, Department of Internal Medicine and Critical Care, Apollo Health City, Road Number 72, opp, Bharatiya Vidya Bhavan School, Jubilee Hills, Hyderabad 500033, India. rajib.paulcriticalcare@gmail.com
Key Words	Acute physiology and chronic health evaluation score; Hemadsorption; Sepsis; Sequential organ failure assessment score; Vasopressor
Core Tip	This prospective, real time, observational multicenter study was conducted in 45 patients with sepsis and septic shock. Post therapy, 26 patients survived and dose reduction in norepinephrine, epinephrine and vasopressin was 51.4%, 69.4% and 13.9%, respectively. Interleukin-6 levels reduction was 52.3% and platelet count improved significantly to 30.1%. Mean acute physiology and chronic health evaluation and sequential organ failure assessment scores reduced significantly. Predicted mortality before CytoSorb® therapy was 56.5% that reduced to 48.8% after CytoSorb® therapy. The survival rate in patients given treatment in < 24 h of intensive care unit admission was 75% and 68% when given within 24-48 h of intensive care unit admission. CytoSorb® therapy was safe and well tolerated with no adverse events reported.
Citation	Paul R, Sathe P, Kumar RS, Prasad S, Aleem M, Sakhalvalkar P. Multicentered prospective investigator initiated study to evaluate the clinical outcomes with extracorporeal cytokine adsorption device (cytoSorb®) in patients with sepsis and septic shock. World J Crit Care Med 2021; 10(1): 22-34

Received	2020-06-02 14:42
Peer-Review Started	2020-06-02 14:43
To Make the First Decision
Return for Revision	2020-07-04 21:53
Revised	2020-11-11 12:48
Second Decision	2020-11-25 11:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-11-29 22:27
Articles in Press	2020-11-29 22:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-12-10 00:51
Typeset the Manuscript	2020-12-28 00:58

ISSN	2220-3141(online)
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