Publication Name	World Journal of Gastroenterology
Manuscript ID	57352
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease: A review
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Wu and Qing-Hua Meng
Funding Agency and Grant Number	Funding Agency Grant Number Municipal Natural Science Foundation of Beijing of China 7192085
Corresponding Author	Qing-Hua Meng, MD, PhD, Chief Doctor, Professor, Department of Critical Care Medicine of Liver Disease, Beijing You-An Hospital, Capital Medical University, No.8 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China. meng_qh@126.com
Key Words	Alcoholic liver disease; Metabolism; Trace elements; Vitamins; Malnutrition; Oxidative stress
Core Tip	Perturbation of micronutrients has been broadly reported to be a common characteristic of patients with Alcoholic liver disease (ALD). In the current study, we provide a review of recent studies that investigated the micronutrients imbalance in patients with ALD with a focus on zinc, iron, copper, magnesium, selenium, vitamin D and vitamin E, as well as dissect how disturbance in micronutrients relates to the pathophysiology of ALD. More importantly, we also highlight several challenges in terms of low sample size, study design discrepancies, sample heterogeneity across studies, and use of machine learning approaches.
Citation	Wu J, Meng QH. Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease. World J Gastroenterol 2020; 26(31): 4567-4578

Received	2020-06-04 13:55
Peer-Review Started	2020-06-04 13:57
To Make the First Decision
Return for Revision	2020-06-18 04:33
Revised	2020-06-22 10:32
Second Decision	2020-07-29 10:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-07-30 05:11
Articles in Press	2020-07-30 05:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-08-10 06:13
Typeset the Manuscript	2020-08-19 10:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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