Publication Name	World Journal of Hepatology
Manuscript ID	57567
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo
Manuscript Source	Invited Manuscript
All Author List	Emma L Shepherd, Sumera Karim, Philip N Newsome and Patricia F Lalor
Funding Agency and Grant Number
Corresponding Author	Patricia F Lalor, BSc, PhD, Academic Research, Reader (Associate Professor), Centre for Liver and Gastroenterology Research, Birmingham National Institute for Health Research, Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, West Midlands, United Kingdom. p.f.lalor@bham.ac.uk
Key Words	Non-alcoholic fatty liver disease; Hepatocyte; Lipid; Cell biology; Vascular adhesion protein-1; Steatosis
Core Tip	Incidence of non-alcoholic fatty liver disease (NAFLD) is dramatically increasing worldwide but to date there are no licenced therapies. The challenge remains management of the diverse pathophysiology from simple steatosis, through inflammation and fibrosis and the systemic complications of the metabolic syndrome. Vascular adhesion protein-1 (VAP-1) is an enzyme with proven contributions to systemic and hepatic glucose handling, inflammation and fibrosis. We now show an additional role in hepatic steatosis. Thus our important data suggests that targeting the semicarbazide sensitive amine oxidase capacity of VAP-1 may represent a useful adjunct to other therapeutic strategies in NAFLD.
Citation	Shepherd EL, Karim S, Newsome PN, Lalor PF. Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo. World J Hepatol 2020; 12(11): 931-948

Received	2020-06-15 18:12
Peer-Review Started	2020-06-15 18:14
To Make the First Decision
Return for Revision	2020-06-20 21:28
Revised	2020-07-23 10:53
Second Decision	2020-09-15 00:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-09-15 17:37
Articles in Press	2020-09-15 17:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-11-17 09:01

ISSN	1948-5182 (online)
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