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9/15/2020 5:37:41 PM | Browse: 19 | Download: 13
Publication Name World Journal of Hepatology
Manuscript ID 57567
Country/Territory United Kingdom
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo
Manuscript Source Invited Manuscript
All Author List Emma L Shepherd, Sumera Karim, Philip N Newsome and Patricia F Lalor
Funding Agency and Grant Number
Corresponding author Patricia F Lalor, BSc, PhD, Academic Research, Reader (Associate Professor), Centre for Liver and Gastroenterology Research, Birmingham National Institute for Health Research, Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, West Midlands, United Kingdom. p.f.lalor@bham.ac.uk
Key Words Non-alcoholic fatty liver disease; Hepatocyte; Lipid; Cell biology; Vascular adhesion protein-1; Steatosis
Core Tip Incidence of non-alcoholic fatty liver disease (NAFLD) is dramatically increasing worldwide but to date there are no licenced therapies. The challenge remains management of the diverse pathophysiology from simple steatosis, through inflammation and fibrosis and the systemic complications of the metabolic syndrome. Vascular adhesion protein-1 (VAP-1) is an enzyme with proven contributions to systemic and hepatic glucose handling, inflammation and fibrosis. We now show an additional role in hepatic steatosis. Thus our important data suggests that targeting the semicarbazide sensitive amine oxidase capacity of VAP-1 may represent a useful adjunct to other therapeutic strategies in NAFLD.
Citation Shepherd EL, Karim S, Newsome PN, Lalor PF. Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo. World J Hepatol 2020; In press
Received
2020-06-15 18:12
Peer-Review Started
2020-06-15 18:14
To Make the First Decision
Return for Revision
2020-06-20 21:28
Revised
2020-07-23 10:53
Second Decision
2020-09-15 00:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-15 17:37
Articles in Press
2020-09-15 17:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ze-Mao Gong
Reviewer Code 03011764, and 00198170
Editorial Director
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 57567-Review.docx
Answering Reviewers 57567-Answering reviewers.pdf
Audio Core Tip 57567-Audio core tip.mp3
Biostatistics Review Certificate 57567-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 57567-Conflict-of-interest statement.pdf
Copyright License Agreement 57567-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 57567-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 57567-Institutional review board statement.pdf
Supplementary Material 57567-Supplementary material.pdf
Peer-review Report 57567-Peer-review(s).pdf
Scientific Misconduct Check 57567-Bing-Gong ZM-2.png
Scientific Misconduct Check 57567-CrossCheck.png
Scientific Misconduct Check 57567-Scientific misconduct check.pdf
Scientific Editor Work List 57567-Scientific editor work list.pdf