Publication Name	World Journal of Clinical Cases
Manuscript ID	58217
Country	China

Category	Neurosciences
Manuscript Type	Case Report
Article Title	Malignant pheochromocytoma with cerebral and skull metastasis: A case report and literature review
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Chen Chen, Dong-Zhou Zhuang, Cheng Luo and Wei-Qiang Chen
Funding Agency and Grant Number
Corresponding Author	Wei-Qiang Chen, MD, PhD, Professor, Department of Neurosurgery, First Affiliated Hospital of Shantou University Medical College, No.57 Changping Road, Shantou 515041, Guangdong Province, China. wqchen2@163.com
Key Words	Malignant pheochromocytoma; Catecholamine-secreting; Cerebral metastasis; Skull metastasis; Meningioma; Magnetic resonance spectroscopy; Case report
Core Tip	Malignant pheochromocytoma with cerebral and skull metastasis is a very rare disease. We present the case of a 60-year-old male patient with malignant cerebral and skull pheochromocytoma who underwent surgical resection. A literature review was performed to provide information on clinical manifestations, radiographic and histopathological features, and treatment strategies. Clinical features may be similar in malignant cerebral pheochromocytoma and meningioma because they have a strong relationship in terms of genetic origin. Magnetic resonance imaging spectroscopy and histopathological examination are necessary to make an accurate differential diagnosis between malignant cerebral pheochromocytoma and meningioma. Different treatment strategies were discussed, including surgery, radiotherapy and chemotherapy.
Citation	Chen JC, Zhuang D, Luo C, Chen W. Malignant pheochromocytoma with cerebral and skull metastasis: A case report and literature review. World J Clin Cases 2021; 9(12): 2791-2800

Received	2020-11-29 12:48
Peer-Review Started	2020-11-29 12:48
To Make the First Decision
Return for Revision	2020-12-21 07:41
Revised	2020-12-31 15:04
Second Decision	2021-02-19 12:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-02-19 18:21
Articles in Press	2021-02-19 18:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-03-01 13:26
Typeset the Manuscript	2021-03-29 03:34

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com