Publication Name	World Journal of Hepatology
Manuscript ID	58399
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Effectiveness of entecavir to prevent hepatocellular carcinoma development is genotype dependent in hepatitis B virus-associated liver cirrhosis
Manuscript Source	Unsolicited Manuscript
All Author List	Kazuo Tarao, Akito Nozaki, Makoto Chuma, Masataka Taguri and Shin Maeda
Funding Agency and Grant Number	Funding Agency Grant Number Kanagawa Association of Medical and Dental Practitioners
Corresponding Author	Kazuo Tarao, MD, PhD, Director, Department of Gastroenterology, Tarao’s Gastroenterological Clinic, 2-58-6, Taiyo Building Futamatagawa, Asahi-ku,, Yokohama City 241-0821, Japan. duoluoweih7@gmail.com
Key Words	Hepatocellular carcinoma; Entecavir; Genotype of hepatitis B virus; Oral nucleos(t)ide analogue
Core Tip	Entecavir was demonstrated to reduce the rate of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) associated liver cirrhosis. The reduction rate of HCC differs in various regions of the world. We surveyed the differences based on published articles using PubMed (2004-2019). On entecavir administration, the incidence of HCC in genotype D regions (1.89 ± 0.28%/year, mean ± SE) was significantly lower than that in genotype C regions (2.91 ± 0.24%/year, P < 0.01). While, concerning the initial HBV-deoxyribonucleic acid levels, that in genotype C patients was nearly the same as that in genotype D patients. The effectiveness of entecavir to prevent HCC development in patient with HBV-associated liver cirrhosis is genotype dependent.
Citation	Tarao K, Nozaki A, Chuma M, Taguri M, Maeda S. Effectiveness of entecavir to prevent hepatocellular carcinoma development is genotype dependent in hepatitis B virus-associated liver cirrhosis. World J Hepatol 2021; 13(1): 144-150

Received	2020-08-31 07:21
Peer-Review Started	2020-08-31 07:21
To Make the First Decision
Return for Revision	2020-11-03 23:52
Revised	2020-11-16 05:46
Second Decision	2020-11-25 11:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-11-29 22:23
Articles in Press	2020-11-29 22:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-12-08 09:17
Typeset the Manuscript	2021-01-24 00:26

ISSN	1948-5182 (online)
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