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Publication Name World Journal of Gastroenterology
Manuscript ID 59038
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Clinical Trials Study
Article Title Effect of postoperative early enteral nutrition on clinical outcomes and immune function of cholangiocarcinoma patients with malignant obstructive jaundice
Manuscript Source Unsolicited Manuscript
All Author List Bing-Qiang Ma, Shi-Yong Chen, Ze-Bin Jiang, Biao Wu, Yu He, Xin-Xin Wang, Yuan Li, Peng Gao and Xiao-Jun Yang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81660398
The Hospital Key Program of National Scientific Research Cultivation Plan 19SYPYA-12
Corresponding Author Xiao-Jun Yang, MD, PhD, Chief Doctor, Professor, Surgeon, Department of General Surgery, Gansu Provincial Hospital, No. 204 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. yangxjmd@aliyun.com
Key Words Clinical outcomes; Early enteral nutrition; Immune function; Nutritional status; Malignant obstructive jaundice; Cholangiocarcinoma
Core Tip The aim of this prospective clinical trial was to investigate the effects of postoperative early enteral nutrition (EEN) on immunity function and clinical outcomes of cholangiocarcinoma patients with malignant obstructive jaundice (MOJ). Patients were randomly divided into the early enteral nutrition +parenteral nutrition (EEN+PN) and total parenteral nutrition (TPN) groups. As a result, the CD3+T, CD4+T, CD8+T, and CD4+T/CD8+T cell counts, and the immunoglobulin (Ig) G, IgM, and IgA levels in the EEN+PN group were significantly higher than those in the TPN group on PODs 3 and 7 (P < 0.05). A postoperative EEN program could improve the clinical outcomes and immune functions of cholangiocarcinoma patients with MOJ and is thus beneficial to patient recovery.
Citation Ma BQ, Chen SY, Jiang ZB, Wu B, He Y, Wang XX, Li Y, Gao P, Yang XJ. Effect of postoperative early enteral nutrition on clinical outcomes and immune function of cholangiocarcinoma patients with malignant obstructive jaundice. World J Gastroenterol 2020; In press
Received
2020-08-27 16:42
Peer-Review Started
2020-08-27 16:43
To Make the First Decision
Return for Revision
2020-11-03 15:01
Revised
2020-11-15 18:28
Second Decision
2020-11-17 12:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-11-21 05:40
Articles in Press
2020-11-21 05:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Chen-Chen Gao
Reviewer Code 03529755, and 00503601
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 59038_Auto_Edited.docx
Answering Reviewers 59038-Answering reviewers.pdf
Audio Core Tip 59038-Audio core tip.mp3
Biostatistics Review Certificate 59038-Biostatistics statement.pdf
Clinical Trial Registration Statement 59038-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 59038-Conflict-of-interest statement.pdf
Copyright License Agreement 59038-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59038-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 59038-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 59038-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 59038-Language certificate.pdf
Peer-review Report 59038-Peer-review(s).pdf
Scientific Misconduct Check 59038-Bing-Yan JP-1.png
Scientific Misconduct Check 59038-Scientific misconduct check.pdf
Scientific Editor Work List 59038-Scientific editor work list.pdf