Publication Name	World Journal of Gastroenterology
Manuscript ID	59038
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Effect of postoperative early enteral nutrition on clinical outcomes and immune function of cholangiocarcinoma patients with malignant obstructive jaundice
Manuscript Source	Unsolicited Manuscript
All Author List	Bing-Qiang Ma, Shi-Yong Chen, Ze-Bin Jiang, Biao Wu, Yu He, Xin-Xin Wang, Yuan Li, Peng Gao and Xiao-Jun Yang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81660398 The Hospital Key Program of National Scientific Research Cultivation Plan 19SYPYA-12
Corresponding Author	Xiao-Jun Yang, MD, PhD, Chief Doctor, Professor, Surgeon, Department of General Surgery, Gansu Provincial Hospital, No. 204 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. yangxjmd@aliyun.com
Key Words	Clinical outcomes; Early enteral nutrition; Immune function; Nutritional status; Malignant obstructive jaundice; Cholangiocarcinoma
Core Tip	The aim of this prospective clinical trial was to investigate the effects of postoperative early enteral nutrition (EEN) on immunity function and clinical outcomes of cholangiocarcinoma patients with malignant obstructive jaundice (MOJ). Patients were randomly divided into the early enteral nutrition +parenteral nutrition (EEN+PN) and total parenteral nutrition (TPN) groups. As a result, the CD3+T, CD4+T, CD8+T, and CD4+T/CD8+T cell counts, and the immunoglobulin (Ig) G, IgM, and IgA levels in the EEN+PN group were significantly higher than those in the TPN group on PODs 3 and 7 (P < 0.05). A postoperative EEN program could improve the clinical outcomes and immune functions of cholangiocarcinoma patients with MOJ and is thus beneficial to patient recovery.
Citation	Ma BQ, Chen SY, Jiang ZB, Wu B, He Y, Wang XX, Li Y, Gao P, Yang XJ. Effect of postoperative early enteral nutrition on clinical outcomes and immune function of cholangiocarcinoma patients with malignant obstructive jaundice. World J Gastroenterol 2020; 26(46): 7405-7415

Received	2020-08-27 16:42
Peer-Review Started	2020-08-27 16:43
To Make the First Decision
Return for Revision	2020-11-03 15:01
Revised	2020-11-15 18:28
Second Decision	2020-11-17 12:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-11-21 05:40
Articles in Press	2020-11-21 05:40
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-11-26 23:11
Typeset the Manuscript	2020-12-09 01:18

ISSN	1007-9327 (print) and 2219-2840 (online)
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