Publication Name	World Journal of Stem Cells
Manuscript ID	59128
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Functional maturation of immature β cells: A roadblock for a stem cell therapy to type 1 diabetes
Manuscript Source	Invited Manuscript
All Author List	Zi-Yi Sun, Ting-Yan Yu, Fang-Xu Jiang and Wei Wang
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China 81471081 Natural Science Foundation of Fujian Province, China 2019J01010 Xiamen Research Foundation for Science and Technology Project 3502Z20194037 Scientific Research Foundation for Advanced Talents, Xiang’an Hospital of Xiamen University PM201809170005
Corresponding Author	Wei Wang, MD, Doctor, Department of Endocrinology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, 2000 Xiang'an East Road, Xiang'an District, Xiamen 361101, Fujian Province, China. wwei19742007@hotmail.com
Key Words	Stem cell therapy; Type 1 diabetes mellitus; β cell; Maturation
Core Tip	Type 1 diabetes is a metabolic disease characterized by absolute lack of insulin. Current insulin replacement therapy supplies insulin in a non-physiological way and is associated with devastating complications. A diabetes stem cell therapy with insulin-producing β-like cells differentiated in vitro from human pluripotent stem cells has recently attracted great interest in the academic community and the general public. Though great progresses have been made, the β-like cells differentiated in vitro differentiation still have many defects. Here we summarize the latest knowledge on β-cell maturation in vivo and in vitro and the vital roles of key molecules in this process, in order to explore the current problems in a diabetes stem cell therapy.
Citation	Sun ZY, Yu TY, Jiang FX, Wang W. Functional maturation of immature β cells: A roadblock for a stem cell therapy to type 1 diabetes. World J Stem Cells 2021; 13(3): 193-207

Received	2020-08-29 04:01
Peer-Review Started	2020-08-29 04:01
To Make the First Decision
Return for Revision	2021-01-07 19:24
Revised	2021-01-19 03:24
Second Decision	2021-01-29 06:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-02-26 03:26
Articles in Press	2021-02-26 03:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-03-08 04:28
Typeset the Manuscript	2021-03-24 06:11

ISSN	1948-0210 (online)
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