Publication Name	World Journal of Gastroenterology
Manuscript ID	59323
Country	China

Category	Research & Experimental Medicine
Manuscript Type	Basic Study
Article Title	Fork head box M1 regulates vascular endothelial growth factor-A expression to promote the angiogenesis and tumor cell growth of gallbladder cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Rui-Tao Wang, Run-Chen Miao, Xing Zhang, Gang-Hua Yang, Yi-Ping Mu, Zi-Yun Zhang, Kai Qu and Chang Liu
Funding Agency and Grant Number	Funding Agency Grant Number Scientific and Technological Development Research Project Foundation of Shaanxi Province of China 2020SF-069
Corresponding Author	Chang Liu, MD, PhD, Chief Doctor, Professor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 West Yanta Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com
Key Words	Gallbladder neoplasms; Fork head box M1; Vascular endothelial growth factor-A; Angiogenesis; Progression; Prognosis
Core Tip	Fork head box M1 (FoxM1) is considered an emerging molecular target associated with early metastasis, drug resistance, and poor patient survival in gallbladder cancer (GBC). Accumulating evidence suggests that vascular endothelial growth factor (VEGF) plays important roles in many kinds of tumors by inducing neoangiogenesis. In the present study, we found that VEGF-A overexpression was correlated with proliferation, invasion and poor prognosis. The results of Kaplan-Meier analysis showed that both FoxM1 and VEGF-A were associated with the survival of GBC. VEGF-A expression was regulated by FoxM1, which was the mechanism of FoxM1 enhancing the angiogenesis of GBC.
Citation	Wang RT, Miao RC, Zhang X, Yang GH, Mu YP, Zhang ZY, Qu K, Liu C. Fork head box M1 regulates vascular endothelial growth factor-A expression to promote the angiogenesis and tumor cell growth of gallbladder cancer. World J Gastroenterol 2021; 27(8): 692-707

Received	2020-09-09 02:58
Peer-Review Started	2020-09-09 02:59
To Make the First Decision
Return for Revision	2020-12-04 00:59
Revised	2020-12-16 09:23
Second Decision	2021-01-20 13:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-01-21 17:33
Articles in Press	2021-01-21 17:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-01-27 21:05
Typeset the Manuscript	2021-02-25 01:22

ISSN	1007-9327 (print) and 2219-2840 (online)
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