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Publication Name World Journal of Transplantation
Manuscript ID 59339
Country/Territory United States
Category Transplantation
Manuscript Type Retrospective Cohort Study
Article Title Risk prediction model for cutaneous squamous cell carcinoma in adult cardiac allograft recipients
Manuscript Source Unsolicited Manuscript
All Author List Nandini Nair, Zhiyong Hu, Dongping Du and Enrique Gongora
Funding Agency and Grant Number
Funding Agency Grant Number
National Science Foundation CMMI-1728338
Corresponding Author Nandini Nair, MD, PhD, Professor, Division of Cardiology, Department of Internal Medicine, Texas Tech Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, United States. nandini.nair@ttuhsc.edu
Key Words Cutaneous squamous cell carcinoma; Heart transplantation; Cox proportional hazard model; Risk assessment; Squamous cell carcinoma; Mortality outcomes
Core Tip We retrospectively analyzed 23736 heart-transplant recipients between 2010 and 2015. Eight risk factors associated with post-transplant cutaneous squamous cell carcinoma were identified, including older age, male sex, lower human leukocyte antigen mismatch level, white race, malignancy at listing, diagnosis with restrictive myopathy or hypertrophic myopathy, heart re-transplant, induction therapy with OKT3 or daclizumab. A multivariate risk prediction model was developed with c-statistics of ≥ 0.77 in both derivation and validation sets. A risk scoring system was designed to stratify patients into 4 risk groups based on their total risk scores. The predicted and observed 5-year probability of developing cutaneous squamous cell carcinoma match well among different risk groups.
Citation Nair N, Hu Z, Du D, Gongora E. Risk prediction model for cutaneous squamous cell carcinoma in adult cardiac allograft recipients. World J Transplant 2021; In press
Received
2020-09-06 20:33
Peer-Review Started
2020-09-06 20:34
To Make the First Decision
Return for Revision
2020-12-01 18:06
Revised
2020-12-25 23:13
Second Decision
2021-02-03 10:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-02-20 04:01
Articles in Press
2021-02-20 04:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2220-3230 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Chen-Chen Gao
Reviewer Code 03293239, and 03650328
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 59339_Auto_Edited_LM.docx
Answering Reviewers 59339-Answering reviewers.pdf
Audio Core Tip 59339-Audio core tip.m4a
Biostatistics Review Certificate 59339-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 59339-Conflict-of-interest statement.pdf
Copyright License Agreement 59339-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59339-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 59339-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 59339-Institutional review board statement.pdf
Peer-review Report 59339-Peer-review(s).pdf
Scientific Misconduct Check 59339-Bing-Chen XF-1.png
Scientific Misconduct Check 59339-Scientific misconduct check.pdf
Scientific Editor Work List 59339-Scientific editor work list.pdf