Publication Name	World Journal of Clinical Cases
Manuscript ID	59531
Country	Canada

Category	Infectious Diseases
Manuscript Type	Systematic Reviews
Article Title	Comparative profile for COVID-19 cases from China and North America: Clinical symptoms, comorbidities and disease biomarkers
Manuscript Source	Invited Manuscript
All Author List	Alaa Badawi and Denitsa Vasileva
Funding Agency and Grant Number
Corresponding Author	Alaa Badawi, PhD, Professor, Senior Researcher, Public Health Risk Sciences Division, Public Health Agency of Canada, 180 Queen Street West, Toronto M5V3L7, ON, Canada. alaa.badawi@canada.ca
Key Words	COVID-19; Symptoms; Comorbidities; China; North America; Adults
Core Tip	The study evaluates the inter-population differences in the susceptibility to acute respiratory syndrome coronavirus-2 or COVID-19 between China and North America. Fever, cough, fatigue and dyspnea were the most common clinical symptoms of COVID-19 in both study regions. Hypertension, diabetes and cancer were the most prevalent comorbidities in COVID-19 cases from China whereas obesity, hypertension and diabetes were the most prevalent in North America. Prevalence of comorbidities in COVID-19 cases increased with age but was at younger ages in cases from China compared to those from North America. Inflammatory markers such as C-reactive protein were 4.5-fold higher in the North American cases than in cases from China. The differences in COVID-19 profile between China and North America reflects the differences in environmental-, host- and healthcare-related factors between the two regions.
Citation	Badawi A, Vasileva D. Comparative profile for COVID-19 cases from China and North America: Clinical symptoms, comorbidities and disease biomarkers. World J Clin Cases 2021; 9(1): 118-132

Received	2020-09-15 14:56
Peer-Review Started	2020-09-15 14:56
To Make the First Decision
Return for Revision	2020-10-18 17:45
Revised	2020-11-02 14:02
Second Decision	2020-11-18 10:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-11-21 05:49
Articles in Press	2020-11-21 05:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-12-28 06:56

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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