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Publication Name World Journal of Gastroenterology
Manuscript ID 59908
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Systematic Reviews
Article Title Predictive value of biologic blood concentration on endoscopic inactivity in inflammatory bowel disease: A systematic review
Manuscript Source Unsolicited Manuscript
All Author List Wan-Ting Cao, Rong Huang, Ke-Fang Jiang, Xue-Hui Qiao, Jing-Jing Wang, Yi-Hong Fan and Yi Xu
Funding Agency and Grant Number
Funding Agency Grant Number
Zhejiang TCM Science and Technology Project 2019ZA056
Zhejiang TCM Science and Technology Project 2016ZA092
Zhejiang TCM Science and Technology Project 2021ZA057
The National Natural Science Foundation of China 81473506
Corresponding Author Yi-Hong Fan, MD, Associate Professor, Chief Doctor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. yhfansjr@163.com
Key Words Inflammatory bowel disease; Biological blood concentration; Endoscopic inactivity; Infliximab; Adalimumab; Vedolizumab
Core Tip Deep remission is considered as the primary endpoint of biological therapy in inflammatory bowel disease. However, it is still difficult to determine or predict whether inflammatory bowel diseases (IBDs) patients achieve deep remission or not. Although endoscopic examinations are widely accepted by gastroenterologists as golden standards on evaluating disease states, majority of IBD patients reject frequent invasive examinations. Hence, new methods of early prediction on therapeutic outcomes of IBD patients under biologics are brought forward by gastroenterologists. Biological blood concentration, one of the major monitoring indicators during biological therapy, exhibits enormous tendency to correlate with outcomes of IBD patients. Nonetheless, biological blood concentration is no substitute for endoscopic examinations in detecting deep lesions. By contrast, combination biological blood concentration and endoscopic examinations is conducive to enhance the accuracy of outcome prediction.
Citation Cao WT, Huang R, Jiang KF, Qiao XH, Wang JJ, Fan YH, Xu Y. Predictive value of biologic blood concentration on endoscopic inactivity in inflammatory bowel disease: A systematic review. World J Gastroenterol 2021; In press
Received
2020-10-17 02:49
Peer-Review Started
2020-10-17 02:49
To Make the First Decision
Return for Revision
2020-12-13 02:23
Revised
2020-12-25 15:07
Second Decision
2021-01-12 12:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-01-12 18:45
Articles in Press
2021-01-12 18:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Le Zhang
Reviewer Code 02540539
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 59908_Auto_Edited.docx
Answering Reviewers 59908-Answering reviewers.pdf
Audio Core Tip 59908-Audio core tip.m4a
Biostatistics Review Certificate 59908-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 59908-Conflict-of-interest statement.pdf
Copyright License Agreement 59908-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59908-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 59908-Language certificate.pdf
Peer-review Report 59908-Peer-review(s).pdf
Scientific Misconduct Check 59908-Bing-Yan JP-1.png
Scientific Misconduct Check 59908-Scientific misconduct check.pdf
Scientific Editor Work List 59908-Scientific editor work list.pdf