Publication Name	World Journal of Clinical Oncology
Manuscript ID	60168
Country	Italy

Category	Oncology
Manuscript Type	Case Report
Article Title	Long term complete response in metastatic poorly-differentiated neuroendocrine rectal carcinoma with multimodal approach: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Silvia Della Torre, Germana de Nucci, Pietro Maria Lombardi, Samuele Grandi, Gianpiero Manes and Roberto Bollina
Funding Agency and Grant Number
Corresponding Author	Silvia Della Torre, MD, Doctor, Oncology Unit, Asst Rhodesien, Corso Europa 2, Rho 20017, Italy. sdellatorre@asst-rhodense.it
Key Words	neuroendocrine tumor; multimodal therapy; case report; rectal carcinoma; surgery; radiotherapy
Core Tip	Neuroendocrine gastrointestinal tumors are rare with different clinical behaviors. Prognostic factors are tumor differentiation, Ki-67 index and presence of distant metastases. Most of them are well differentiated neuroendocrine tumors with a good prognosis and a 5-year overall survival of 60–90%. Surgery is the gold standard treatment in local and metastatic disease, while radiotherapy is ineffective. Poorly differentiated neuroendocrine carcinomas (NECs) represent only 5–10% among digestive NETS. Here we describe a rare case of a patient with a diagnosis of poorly differentiated rectal metastatic NEC treated with a different treatment approach and with a complete remission (CR) after 5 years.
Citation	Della Torre S, de Nucci G, Lombardi PM, Grandi S, Manes G, Bollina R. Long-term complete response in metastatic poorly-differentiated neuroendocrine rectal carcinoma with a multimodal approach: A case report. World J Clin Oncol 2021; 12(6): 500-506

Received	2020-10-23 11:11
Peer-Review Started	2020-10-23 11:12
To Make the First Decision
Return for Revision	2020-12-04 16:08
Revised	2020-12-24 17:29
Second Decision	2021-03-03 06:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-03-03 16:50
Articles in Press	2021-03-03 16:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-15 15:14
Typeset the Manuscript	2021-05-31 08:58

ISSN	2218-4333 (online)
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