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Publication Name World Journal of Gastroenterology
Manuscript ID 60309
Country/Territory China
Category Medicine, General and Internal
Manuscript Type Basic Study
Article Title Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats
Manuscript Source Unsolicited Manuscript
All Author List Jin-Dong Zhao, Yan Li, Min Sun, Chan-Juan Yu, Jia-Yun Li, Si-Hai Wang, Di Yang, Cheng-Lin Guo, Xue Du, Wen-Jin Zhang, Ruo-Dong Cheng, Xiao-Chuan Diao and Zhao-Hui Fang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81603574
National Natural Science Foundation of China 81774286
National Key Research and Development Program 2018YFC1704202
National Key Research and Development Program 2020YFE0201800
University Scientific Research Projects of Anhui KJ2019A0442
Province Science Foundation of Anhui 1708085QH213
Corresponding Author Zhao-Hui Fang, PhD, Chief Doctor, Department of Endocrinology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei 230031, Anhui Province, China. fangzhaohui1111@163.com
Key Words Type 2 diabetes mellitus; Amelioration of hyperglycaemia; Modulation of gut microbiota; Berberine; Metformin; Goto-Kakizaki rats
Core Tip Recent studies suggested that the gut microbiota has an essential role in type 2 diabetes mellitus. Our study verifies the effects of berberine in regulating glucose metabolism and reducing pancreas injury in Goto-Kakizaki rats. Berberine also provides an alternative means of modulating the gut microbiota. Results revealed evidence of a decrease in Desulfobacterota, Desulfovibrionaceae and Clostridia_UCG-014 and an increase in Verrucomicrobiota, Akkermansia and Allobaculum. The correlation analysis indicated that fasting blood glucose was strongly positively correlated with Clostridia_UCG-014 and negatively correlated with Allobaculum.
Citation Zhao JD, Li Y, Sun M, Yu CJ, Li JY, Wang SH, Yang D, Guo CL, Du X, Zhang WJ, Cheng RD, Diao XC, Fang ZH. Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats. World J Gastroenterol 2021; In press
Received
2020-10-24 11:17
Peer-Review Started
2020-10-24 11:18
To Make the First Decision
Return for Revision
2020-11-23 05:33
Revised
2020-12-17 03:32
Second Decision
2021-01-13 13:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-01-13 17:59
Articles in Press
2021-01-13 17:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-01-27 02:24
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Chen-Chen Gao
Reviewer Code 03477900, and 05403223
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor Tian-Qi Wang
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 60309_Auto_Edited_WangTQ.docx
Answering Reviewers 60309-Answering reviewers.pdf
Audio Core Tip 60309-Audio core tip.m4a
Biostatistics Review Certificate 60309-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 60309-Conflict-of-interest statement.pdf
Copyright License Agreement 60309-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 60309-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 60309-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 60309-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 60309-Language certificate.pdf
Peer-review Report 60309-Peer-review(s).pdf
Scientific Misconduct Check 60309-Bing-Gao CC-1.jpg
Scientific Misconduct Check 60309-Scientific misconduct check.pdf
Scientific Editor Work List 60309-Scientific editor work list.pdf