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Publication Name World Journal of Gastroenterology
Manuscript ID 60342
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Xiangbinfang granules enhance gastric antrum motility via intramuscular interstitial cells of Cajal in mice
Manuscript Source Unsolicited Manuscript
All Author List Qi-Cheng Chen, Zhi Jiang, Jun-Hong Zhang, Li-Xing Cao and Zhi-Qiang Chen
Funding Agency and Grant Number
Funding Agency Grant Number
Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine YN10101902
National Regional Traditional Chinese Medicine (Specialist) Clinic Construction (2018)205
Corresponding Author Zhi-Qiang Chen, MD, Professor, The Research Team of TCM Applications of Perioperative, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 111 Dade Road, Guangzhou 510120, Guangdong Province, China. wssq@gzucm.edu.cn
Key Words Interstitial cells of Cajal; Migrating motor complex; W/Wv; Gastric antrum motility; Xiangbinfang granule; Chinese medicine
Core Tip This study shows that intramuscular interstitial cells of Cajal (ICC-IM) play crucial roles in regulating the gastric antral migrating motor complexes (MMC) activity. It may be an important bridge between vagus, the enteric nervous system and motilin to regulate smooth muscle contraction. Through the muscarinic receptor pathway on ICC-IM, the Chinese medicine Xiangbinfang granule depolarizes smooth muscle cells and initiates an action potential, changing the periodic motion of MMC into a phase III-like contractions pattern of gastric antrum in mice.
Citation Chen QC, Jiang Z, Zhang JH, Cao LX, Chen ZQ. Xiangbinfang granules enhance gastric antrum motility via intramuscular interstitial cells of Cajal in mice. World J Gastroenterol 2021; 27(7): 576-591
Received
2020-10-27 01:45
Peer-Review Started
2020-10-27 01:46
To Make the First Decision
Return for Revision
2020-12-13 02:19
Revised
2020-12-24 11:12
Second Decision
2021-01-13 13:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-01-13 17:51
Articles in Press
2021-01-13 17:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-01-27 05:29
Typeset the Manuscript
2021-02-19 03:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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