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Publication Name World Journal of Gastroenterology
Manuscript ID 60647
Country/Territory Brazil
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease
Manuscript Source Unsolicited Manuscript
All Author List Katia Farias e Silva, Hayandra F Nanini, Cynthia Machado Cascabulho, Siane L B Rosas, Patricia T Santana, Antonio José de V Carneiro, Elias Anaissie, Marcio Nucci and Heitor Siffert Pereira de Souza
Funding Agency and Grant Number
Funding Agency Grant Number
FAPERJ (Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro E26/202.781/2017
Brazilian Research Council (CNPq) 306634/2019-8
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) 31001017048P0
Corresponding Author Heitor Siffert Pereira de Souza, MD, PhD, Associate Research Scientist, Full Professor, Department of Clinical Medicine, School of Medicine, Federal University of Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, Cidade Universitaria, Rio de Janeiro 21941-913, Brazil. hsouza@hucff.ufrj.br
Key Words Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease; Beta-glucan; Histologic activity; Noninvasive test
Core Tip This study investigated whether serum concentrations of beta-glucan (BG), which originate from the gut microbiota, could reflect active intestinal inflammation in inflammatory bowel diseases patients. BG levels paralleled the endoscopic activity in Crohn’s disease (CD) patients and histologic activity and combined endoscopic and histologic activity in both CD and ulcerative colitis patients. The BG results were better for predicting histologic inflammation than fecal calprotectin. Regarding the endoscopic and histologic activities, the BG levels were reduced following therapeutic intervention in both CD and ulcerative colitis patients. Serum BG levels may represent a novel noninvasive approach to detect mucosal inflammation and therapeutically monitor inflammatory bowel diseases.
Citation Farias e Silva K, Nanini HF, Cascabulho CM, Rosas SLB, Santana PT, Carneiro AJV, Anaissie E, Nucci M, de Souza HSP. Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease. World J Gastroenterol 2021; 27(9): 866-885
Received
2020-11-11 20:27
Peer-Review Started
2020-11-11 20:28
To Make the First Decision
Return for Revision
2020-12-31 01:50
Revised
2021-01-11 20:17
Second Decision
2021-02-18 13:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-02-18 21:19
Articles in Press
2021-02-18 21:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-03-02 00:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Le Zhang
Reviewer Code 03713791, 03474080, 03478404, 03713791, and 03478404
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Production Editor Yu-Jie Ma
Responsible Production Editor Yu-Jie Ma
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJG-27-866.pdf
Full Article (Word) WJG-27-866.docx
Manuscript File 60647_Auto_Edited_LM.docx
Answering Reviewers 60647-Answering reviewers.pdf
Audio Core Tip 60647-Audio core tip.m4a
Biostatistics Review Certificate 60647-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 60647-Conflict-of-interest statement.pdf
Copyright License Agreement 60647-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 60647-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 60647-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 60647-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 60647-Language certificate.pdf
Supplementary Material 60647-Supplementary material.pdf
Peer-review Report 60647-Peer-review(s).pdf
Scientific Misconduct Check 60647-Scientific misconduct check.pdf
Scientific Editor Work List 60647-Scientific editor work list.pdf