Publication Name	World Journal of Gastroenterology
Manuscript ID	60647
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Katia Farias e Silva, Hayandra F Nanini, Cynthia Machado Cascabulho, Siane L B Rosas, Patricia T Santana, Antonio José de V Carneiro, Elias Anaissie, Marcio Nucci and Heitor Siffert Pereira de Souza
Funding Agency and Grant Number	Funding Agency Grant Number FAPERJ (Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro E26/202.781/2017 Brazilian Research Council (CNPq) 306634/2019-8 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) 31001017048P0
Corresponding Author	Heitor Siffert Pereira de Souza, MD, PhD, Associate Research Scientist, Full Professor, Department of Clinical Medicine, School of Medicine, Federal University of Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, Cidade Universitaria, Rio de Janeiro 21941-913, Brazil. hsouza@hucff.ufrj.br
Key Words	Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease; Beta-glucan; Histologic activity; Noninvasive test
Core Tip	This study investigated whether serum concentrations of beta-glucan (BG), which originate from the gut microbiota, could reflect active intestinal inflammation in inflammatory bowel diseases patients. BG levels paralleled the endoscopic activity in Crohn’s disease (CD) patients and histologic activity and combined endoscopic and histologic activity in both CD and ulcerative colitis patients. The BG results were better for predicting histologic inflammation than fecal calprotectin. Regarding the endoscopic and histologic activities, the BG levels were reduced following therapeutic intervention in both CD and ulcerative colitis patients. Serum BG levels may represent a novel noninvasive approach to detect mucosal inflammation and therapeutically monitor inflammatory bowel diseases.
Citation	Farias e Silva K, Nanini HF, Cascabulho CM, Rosas SLB, Santana PT, Carneiro AJV, Anaissie E, Nucci M, de Souza HSP. Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease. World J Gastroenterol 2021; 27(9): 866-885

Received	2020-11-11 20:27
Peer-Review Started	2020-11-11 20:28
To Make the First Decision
Return for Revision	2020-12-31 01:50
Revised	2021-01-11 20:17
Second Decision	2021-02-18 13:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-02-18 21:19
Articles in Press	2021-02-18 21:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-03-02 00:27

ISSN	1007-9327 (print) and 2219-2840 (online)
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