Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	60715
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Combination of preoperative fibrinogen and D-dimer as a prognostic indicator in pancreatic ductal adenocarcinoma patients undergoing R0 resection
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Peng Zhang, Hu Ren, Yong-Xing Du, Xiao-Hao Zheng, Zong-Ming Zhang and Cheng-Feng Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81972314 Innovation Fund for Medical Sciences of Chinese Academy of Medical Sciences 2016-I2M-1-001
Corresponding Author	Cheng-Feng Wang, MD, Chief Doctor, Professor, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. ywwangchengfeng@163.com
Key Words	Pancreatic ductal adenocarcinoma; R0 resection; Fibrinogen; D-dimer; Prognosis; Survival
Core Tip	Both fibrinogen and D-dimer have been demonstrated to be independent predictors of overall survival (OS) in many patients with solid malignancies. We retrospectively analyzed the medical records of 282 patients with pancreatic ductal adenocarcinoma (PDAC) undergoing radical R0 resection. Our study confirms the synergistic value of fibrinogen and D-dimer in predicting OS, and low preoperative fibrinogen and D-dimer concentrations can indicate prolonged OS in PDAC patients undergoing radical R0 resection.
Citation	Zhang LP, Ren H, Du YX, Zheng XH, Zhang ZM, Wang CF. Combination of preoperative fibrinogen and D-dimer as a prognostic indicator in pancreatic ductal adenocarcinoma patients undergoing R0 resection. World J Gastrointest Surg 2021; 13(3): 279-302

Received	2020-11-10 11:31
Peer-Review Started	2020-11-10 11:31
To Make the First Decision
Return for Revision	2020-12-20 03:48
Revised	2021-01-01 17:33
Second Decision	2021-01-12 00:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-01-21 19:47
Articles in Press	2021-01-21 19:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-01-27 05:29
Typeset the Manuscript	2021-03-16 01:32

ISSN	1948-9366 (online)
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