Publication Name	World Journal of Gastroenterology
Manuscript ID	60749
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment
Manuscript Source	Unsolicited Manuscript
All Author List	Ming Yang and Chun-Ye Zhang
Funding Agency and Grant Number
Corresponding Author	Ming Yang, DVM, PhD, Postdoctoral Fellow, Department of Surgery, University of Missouri, One hospital Dr. Medical Science Building, Columbia, MO 65212, United States. yangmin@health.missouri.edu
Key Words	Nonalcoholic fatty liver disease; G protein-coupled receptors; Metabolism; Bile acids; Short-chain fatty acids; Gut microbiota
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Without effective treatment, NAFLD can progress to fibrosis, cirrhosis, and final liver cancer. Currently, there is no efficacy treatment option, except the preventative strategies such as diet selection and excises. G protein-coupled receptors (GPCRs) have been shown to play essential roles in metabolic disorders, such as NAFLD and obesity, through their function as receptors for bile acids and free fatty acids. Therapies such as probiotics and GPCR agonists could be applied to modulate GPCR function to ameliorate liver metabolism syndrome. Herein, this review summarizes the current findings regarding the role of GPCRs in the development and progression of NAFLD and describes some preclinical and clinical studies of GPCR-mediated treatment.
Citation	Yang M, Zhang CY. G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment. World J Gastroenterol 2021; 27(8): 677-691

Received	2020-11-11 21:57
Peer-Review Started	2020-11-11 21:57
To Make the First Decision
Return for Revision	2020-12-17 23:05
Revised	2020-12-24 04:15
Second Decision	2021-01-21 13:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-01-21 18:32
Articles in Press	2021-01-21 18:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-01-25 19:23
Typeset the Manuscript	2021-02-08 03:15

ISSN	1007-9327 (print) and 2219-2840 (online)
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