Publication Name	World Journal of Gastroenterology
Manuscript ID	60780
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Development and validation of a prognostic model for patients with hepatorenal syndrome: A retrospective cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Yu Sheng, Fei-Yan Lin, Jian Wu and Hong-Cui Cao
Funding Agency and Grant Number	Funding Agency Grant Number Chinese High Tech Research & Development (863) Program 2013AA020102
Corresponding Author	Hong-Cui Cao, MD, PhD, Professor, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. hccao@zju.edu.cn
Key Words	Hepatorenal syndrome; Prognostic factor; Mean corpuscular hemoglobin concentration; Mortality; Scoring system; Cohort study
Core Tip	This multicenter retrospective cohort study investigated the prognostic factors for patients with hepatorenal syndrome (HRS) and developed a novel prognostic model, named GIMNS. GIMNS contains five prognostic factors, comprising gender, international normalized ratio, mean corpuscular hemoglobin concentration (MCHC), neutrophil percentage, and stage, which had different expression levels between survivors and non-survivors. Stage, defined according to the number of organ failures and MCHC were found to be effective prognostic factors for the first time. The area under the operating characteristic curve reached 0.830 for 28-d mortality. GIMNS score showed better accuracy than Model for End-Stage Liver Disease, Chronic Liver Failure-Sequential Organ Failure Assessment, and Chinese Group on the Study of Severe Hepatitis B-Acute-on-Chronic Liver Failure.
Citation	Sheng XY, Lin FY, Wu J, Cao HC. Development and validation of a prognostic model for patients with hepatorenal syndrome: A retrospective cohort study. World J Gastroenterol 2021; 27(20): 2615-2629

Received	2020-11-13 03:54
Peer-Review Started	2020-11-13 03:56
To Make the First Decision
Return for Revision	2021-02-11 03:52
Revised	2021-02-23 14:13
Second Decision	2021-04-08 12:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-08 16:00
Articles in Press	2021-04-08 16:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-26 09:35
Typeset the Manuscript	2021-05-19 00:47

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com