Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	61126
Country	Switzerland

Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Matteo Mueller, Marcel André Schneider, Barla Deplazes, Daniela Cabalzar-Wondberg, Andreas Rickenbacher and Matthias Turina
Funding Agency and Grant Number
Corresponding Author	Matthias Turina, MD, PhD, Professor, Department of Surgery and Transplantation, University Hospital Zurich, Raemistrasse 100, Zurich 8091, Switzerland. matthias.turina@usz.ch
Key Words	Young-onset colorectal cancer; Tumor biology; Colorectal surgery; Tumor aggressiveness; Colorectal cancer; Colorectal cancer screening
Core Tip	We evaluated differences in tumor biology between young-onset colorectal cancer patients (< 50 years of age) and late-onset colorectal cancer (CRC) patients (≥ 50 years of age) in a Swiss tertiary cancer center over a six-year period. Parameters of interest included clinical as well as histopathological characteristics. This study reports a surprisingly high rate of CRC of young-onset, while affected patients present more frequently with locally advanced tumors, lymphatic invasion and with more frequent lymphatic metastases. This work puts cancer incidence in relation to histopathological details, mutational status, surgical parameters and selected risk factors.
Citation	Mueller M, Schneider MA, Deplazes B, Cabalzar-Wondberg D, Rickenbacher A, Turina M. Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study. World J Gastrointest Surg 2021; 13(2): 164-175

Received	2020-11-24 22:08
Peer-Review Started	2020-11-24 22:08
To Make the First Decision
Return for Revision	2020-12-20 03:33
Revised	2021-01-02 20:40
Second Decision	2021-01-12 00:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-01-21 20:50
Articles in Press	2021-01-21 20:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-02-01 05:58

ISSN	1948-9366 (online)
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