Publication Name	World Journal of Gastroenterology
Manuscript ID	61139
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Washed microbiota transplantation reduces proton pump inhibitor dependency in nonerosive reflux disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Mei Zheng, Xian-Yun Chen, Jie-Yi Cai, Yu Yuan, Wen-Rui Xie, Jia-Ting Xu, Harry Hua-Xiang Xia, Min Zhang, Xing-Xiang He and Li-Hao Wu
Funding Agency and Grant Number
Corresponding Author	Li-Hao Wu, MD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, No. 19 Nonglinxia Road, Yuexiu District, Guangzhou 510030, Guangdong Province, China. wulihao888@126.com
Key Words	Nonerosive reflux disease; Washed microbiota transplantation; Proton pump inhibitor dependency; Intestinal bacteria; Lipopolysaccharide; Small intestinal bacterial overgrowth
Core Tip	In this study, we demonstrate for the first time that washed microbiota transplantation (WMT) is safe and effective for treating patients with nonerosive reflux disease (NERD) and proton pump inhibitor (PPI) dependency compared with PPI treatment. WMT significantly relieved the symptoms of NERD in patients, reduced PPI dependency, prolonged the duration of symptom remission and reduced symptom recurrence.
Citation	Zheng YM, Chen XY, Cai JY, Yuan Y, Xie WR, Xu JT, Xia HHX, Zhang M, He XX, Wu LH. Washed microbiota transplantation reduces proton pump inhibitor dependency in nonerosive reflux disease. World J Gastroenterol 2021; 27(6): 513-522

Received	2020-11-29 10:43
Peer-Review Started	2020-11-29 10:43
To Make the First Decision
Return for Revision	2020-12-08 02:26
Revised	2020-12-20 07:37
Second Decision	2021-01-12 12:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-01-12 18:36
Articles in Press	2021-01-12 18:36
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-01-24 08:24
Typeset the Manuscript	2021-01-28 07:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com