Publication Name	World Journal of Clinical Cases
Manuscript ID	61364
Country	South Korea

Category	Oncology
Manuscript Type	Case Report
Article Title	Detection of epidermal growth factor receptor-SEPT14 fusion in cell-free DNA of a patient with advanced gastric cancer: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Boyeon Kim, Yoonjung Kim, Inho Park, Jae Yong Cho and Kyung-A Lee
Funding Agency and Grant Number
Corresponding Author	Kyung-A Lee, MD, PhD, Full Professor, Department of Laboratory Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-Ro, Gangnam-Gu, Seoul 06273, South Korea. kal1119@yuhs.ac
Key Words	Gene fusion; Cell-Free DNA; Liquid biopsy; Gastric cancer; Epidermal growth factor receptor tyrosine kinase inhibitor; Case report
Core Tip	In recent decades, increasing application of next-generation sequencing (NGS) has enabled detection of molecular aberrations, including fusions. In cases where tissue is not easily obtainable, cell-free DNA (cfDNA) is used for detecting mutations to determine the molecular profile of cancer. In this study, we report the first case of epidermal growth factor receptor-SEPT14 fusion detected from NGS analysis of cfDNA from a patient with advanced gastric cancer. We suggest expanded applications of the cfDNA assay regardless of cancer type, which may open a new horizon in treatment of patients with advanced gastric cancer.
Citation	Kim B, Kim YJ, Park I, Cho JY, Lee KA. Detection of epidermal growth factor receptor-SEPT14 fusion in cell-free DNA of a patient with advanced gastric cancer: A case report. World J Clin Cases 2021; 9(12): 2884-2889

Received	2020-12-04 03:22
Peer-Review Started	2020-12-04 03:24
To Make the First Decision
Return for Revision	2021-01-24 17:42
Revised	2021-02-02 03:38
Second Decision	2021-03-01 09:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-03-03 17:52
Articles in Press	2021-03-03 17:52
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-03-07 21:48
Typeset the Manuscript	2021-04-08 12:11

ISSN	2307-8960 (online)
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