Publication Name	World Journal of Gastroenterology
Manuscript ID	61406
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Helicobacter pylori: Commensal, symbiont or pathogen?
Manuscript Source	Invited Manuscript
All Author List	Vasiliy Ivanovich Reshetnyak, Alexandr Igorevich Burmistrov and Igor Veniaminovich Maev
Funding Agency and Grant Number
Corresponding Author	Vasiliy Ivanovich Reshetnyak, DSc, MD, PhD, Full Professor, Department of Propaedeutic of Internal Diseases and Gastroenterology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, p. 1, 20 Delegatskaya Street, Moscow 127473, Russia. vasiliy.reshetnyak@yandex.ru
Key Words	Helicobacter pylori; Pathogen; Commensal; Microbiome; Peptic ulcer; Gastric cancer; Asthma; Inflammatory bowel diseases
Core Tip	The review provides data on Helicobacter pylori (H. pylori, HP) as one of the recently identified human bacterial pathogens. On the one hand, its role as a human pathogenic bacterium that is commonly found in patients with chronic gastritis, peptic ulcer disease, and gastric cancer is discussed. On the other hand, the high prevalence of H. pylori in the population and its asymptomatic coexistence with a human being in most of the world’s population indicates its persistence in the body as a representative of the microbiome and as a nonpathogenic microorganism. The presented data suggest that there is an apparent ambiguity of the problem and a need for an analytically developed, comprehensive approach to studying the effect of HP infection on human health and to performing eradication therapy.
Citation	Reshetnyak VI, Burmistrov AI, Maev IV. Helicobacter pylori: Commensal, symbiont or pathogen? World J Gastroenterol 2021; 27(7): 545-560

Received	2020-12-05 16:53
Peer-Review Started	2020-12-05 16:55
To Make the First Decision
Return for Revision	2020-12-27 20:48
Revised	2020-12-28 13:15
Second Decision	2021-01-20 13:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-01-21 18:57
Articles in Press	2021-01-21 18:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-01-30 08:32
Typeset the Manuscript	2021-02-19 03:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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