Publication Name	World Journal of Clinical Cases
Manuscript ID	61530
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Teng-Fei Yin, Dong-Yan Zhao, Yuan-Chen Zhou, Qian-Qian Wang and Shu-Kun Yao
Funding Agency and Grant Number	Funding Agency Grant Number National Key Development Plan for Precision Medicine Research 2017YFC0910002
Corresponding Author	Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Key Words	CircRNA; MiRNA; Network; Colorectal cancer; Prognosis; Biomarkers
Core Tip	The biological functions of circRNA and miRNA interactions and their potential as noninvasive biomarkers have not been well elucidated in colorectal cancer (CRC). In this study, we constructed a circRNA-miRNA-mRNA regulatory network with 19 circRNAs, 13 miRNAs and 28 mRNAs. GO and KEGG analyses indicated several signaling pathways probably involved in tumorigenesis. After being combined with survival analysis, a prognostic subnetwork was constructed including 5 circRNAs, 3 miRNAs and 3 mRNAs, which may represent novel diagnostic and prognostic candidate biomarkers, as well as therapeutic targets of CRC.
Citation	Yin TF, Zhao DY, Zhou YC, Wang QQ, Yao SK. Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer. World J Clin Cases 2021; 9(18): 4520-4541

Received	2020-12-11 08:52
Peer-Review Started	2020-12-11 08:54
To Make the First Decision
Return for Revision	2021-01-19 09:38
Revised	2021-01-26 11:20
Second Decision	2021-02-25 13:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-02-26 18:48
Articles in Press	2021-02-26 18:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-28 03:28
Typeset the Manuscript	2021-06-03 07:11

ISSN	2307-8960 (online)
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